ABCG2 gene
E856800
The ABCG2 gene encodes a membrane transporter protein involved in multidrug resistance and the efflux of various xenobiotics and endogenous compounds across cellular membranes.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| ABCG2 | 0 |
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf | gene ⓘ |
| associatedWith |
clinical multidrug resistance in cancer
ⓘ
gout ⓘ hyperuricemia ⓘ pharmacokinetics of many drugs ⓘ |
| belongsToFamily | ATP-binding cassette transporter family ⓘ |
| belongsToSubfamily | ABC subfamily G NERFINISHED ⓘ |
| encodes |
ABCG2 protein
NERFINISHED
ⓘ
ATP-binding cassette sub-family G member 2 NERFINISHED ⓘ BCRP NERFINISHED ⓘ MXR ⓘ breast cancer resistance protein NERFINISHED ⓘ mitoxantrone resistance protein NERFINISHED ⓘ |
| hasBiologicalProcess |
heme transport
ⓘ
multidrug resistance ⓘ porphyrin transport ⓘ protection of stem cells from xenobiotics ⓘ uric acid transport ⓘ xenobiotic efflux ⓘ |
| hasCellularComponent |
apical plasma membrane
ⓘ
plasma membrane ⓘ |
| hasMolecularFunction |
ATP-dependent transmembrane transporter activity
ⓘ
drug transmembrane transporter activity ⓘ xenobiotic-transporting ATPase activity ⓘ |
| hasPolymorphism | Q141K variant ⓘ |
| HGNCID | HGNC:73 ⓘ |
| highlyExpressedIn |
blood-brain barrier endothelial cells
ⓘ
hematopoietic stem cells ⓘ intestine ⓘ kidney ⓘ liver ⓘ placenta ⓘ |
| locatedOnChromosome | human chromosome 4q22 ⓘ |
| NCBIGeneID | 9429 ⓘ |
| playsRoleIn |
maternal-fetal xenobiotic barrier in placenta
ⓘ
protection of blood-brain barrier from xenobiotics ⓘ |
| Q141KVariantAssociatedWith |
altered drug disposition
ⓘ
increased risk of gout ⓘ reduced transporter activity ⓘ |
| regulatedBy |
estrogen receptor signaling
ⓘ
hypoxia-inducible factors ⓘ nuclear receptors PXR and CAR NERFINISHED ⓘ |
| transportSubstrate |
anticancer drugs
ⓘ
fluoroquinolone antibiotics ⓘ glucuronide conjugates ⓘ methotrexate NERFINISHED ⓘ mitoxantrone ⓘ statins ⓘ sulfate conjugates ⓘ topotecan ⓘ uric acid ⓘ |
| uniprotID | Q9UNQ0 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.