Cdc28
E556655
cell cycle regulator
cyclin-dependent kinase
protein kinase
protein-coding gene
serine/threonine protein kinase
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| CDC28 gene | 0 |
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
cell cycle regulator
ⓘ
cyclin-dependent kinase ⓘ protein kinase ⓘ protein-coding gene ⓘ serine/threonine protein kinase ⓘ |
| activatedBy | cyclin binding ⓘ |
| cellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| commonName | Cdc28p NERFINISHED ⓘ |
| discoveredIn | cell division cycle mutant screens in yeast ⓘ |
| encodedBy | CDC28 gene NERFINISHED ⓘ |
| essentialFor | viability of Saccharomyces cerevisiae ⓘ |
| formsComplexWith |
B-type cyclins
NERFINISHED
ⓘ
Clb1 ⓘ Clb2 ⓘ Clb3 NERFINISHED ⓘ Clb4 ⓘ Clb5 ⓘ Clb6 NERFINISHED ⓘ Cln1 ⓘ Cln2 ⓘ Cln3 NERFINISHED ⓘ G1 cyclins ⓘ |
| hasBiologicalProcess |
DNA replication initiation
ⓘ
G1/S transition of mitotic cell cycle ⓘ G2/M transition of mitotic cell cycle ⓘ bud emergence ⓘ cell cycle ⓘ cell cycle checkpoint control ⓘ mating-type switching ⓘ mitosis ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
cyclin-dependent protein kinase activity ⓘ protein serine/threonine kinase activity ⓘ |
| organism | Saccharomyces cerevisiae NERFINISHED ⓘ |
| orthologOf | Cdk1 NERFINISHED ⓘ |
| regulatedBy |
Cdc25 homolog Mih1
NERFINISHED
ⓘ
Cks1 ⓘ Far1 NERFINISHED ⓘ Mih1 NERFINISHED ⓘ Sic1 NERFINISHED ⓘ Swe1 NERFINISHED ⓘ phosphorylation ⓘ |
| requires | cyclin ⓘ |
| substrate |
Cdh1
NERFINISHED
ⓘ
Far1 NERFINISHED ⓘ Sic1 NERFINISHED ⓘ Whi5 NERFINISHED ⓘ components of the pre-replicative complex ⓘ transcription factors regulating G1/S genes ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.