CYP2J2

E242413
cytochrome P450 enzyme drug-metabolizing enzyme monooxygenase protein-coding gene

CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (4)

Label Occurrences
CYP2J2 canonical 2
CYP2J2 gene 1
CYP2J2*7 1

Statements (68)

Predicate Object
instanceOf cytochrome P450 enzyme ⓘ
drug-metabolizing enzyme ⓘ
monooxygenase ⓘ
protein-coding gene ⓘ
alias CYP2J2 ⓘ
surface form: CYP2J2 gene

CYP2J2 ⓘ
surface form: cytochrome P450, family 2, subfamily J, polypeptide 2
associatedWith anti-inflammatory effects via EETs ⓘ
cardioprotection ⓘ
cardiovascular homeostasis ⓘ
regulation of vascular tone ⓘ
biologicalProcess arachidonic acid metabolic process ⓘ
drug metabolic process ⓘ
epoxyeicosatrienoic acid biosynthetic process ⓘ
epoxygenase P450 pathway ⓘ
xenobiotic metabolic process ⓘ
cellularLocation endoplasmic reticulum ⓘ
clinicalRelevance interindividual variability in drug response ⓘ
potential association with coronary artery disease risk ⓘ
cofactor heme ⓘ
CYPFamily CYP2 ⓘ
CYPMember 2 ⓘ
CYPSubfamily J ⓘ
encodes cytochrome P450 2J2 ⓘ
enzymeCommissionNumber 1.14.14.1 ⓘ
expressedIn brain ⓘ
endothelium ⓘ
heart ⓘ
kidney ⓘ
liver ⓘ
lung ⓘ
pancreas ⓘ
skeletal muscle ⓘ
small intestine ⓘ
testis ⓘ
foundInTaxon Homo sapiens ⓘ
geneSymbol CYP2J2 self-link ⓘ
inhibitedBy danazol ⓘ
fluconazole ⓘ
grapefruit juice components ⓘ
itraconazole ⓘ
ketoconazole ⓘ
locatedIn 1p31.3 ⓘ
chromosome 1 ⓘ
metabolizes albendazole ⓘ
amiodarone ⓘ
astemizole ⓘ
cisapride ⓘ
doxorubicin ⓘ
ebastine ⓘ
ritonavir ⓘ
terfenadine ⓘ
molecularFunction arachidonic acid monooxygenase activity ⓘ
epoxygenase activity ⓘ
heme binding ⓘ
iron ion binding ⓘ
oxidoreductase activity ⓘ
pathway arachidonic acid epoxygenase pathway ⓘ
drug metabolism by cytochrome P450 ⓘ
polymorphism CYP2J2 self-linksurface differs ⓘ
surface form: CYP2J2*7
product epoxyeicosatrienoic acids ⓘ
epoxyoctadecenoic acids ⓘ
requires NADPH ⓘ
cytochrome P450 reductase ⓘ
substrate arachidonic acid ⓘ
docosahexaenoic acid ⓘ
eicosapentaenoic acid ⓘ
linoleic acid ⓘ
uniprotId P51589 ⓘ

Referenced by (5)

Full triples — surface form annotated when it differs from this entity's canonical label.

Xarelto → isMetabolizedBy → CYP2J2 ⓘ
CYP2J2 → geneSymbol → CYP2J2 self-link ⓘ
CYP2J2 → polymorphism → CYP2J2 self-linksurface differs ⓘ
this entity surface form: CYP2J2*7
CYP2J2 → alias → CYP2J2 ⓘ
this entity surface form: cytochrome P450, family 2, subfamily J, polypeptide 2
CYP2J2 → alias → CYP2J2 ⓘ
this entity surface form: CYP2J2 gene