cytochrome P450 reductase
E850009
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
NADPH-dependent reductase
ⓘ
flavoprotein enzyme ⓘ oxidoreductase ⓘ |
| affects |
bioactivation of prodrugs
ⓘ
clearance of many drugs ⓘ formation of reactive drug metabolites ⓘ |
| belongsToFamily | diflavin reductases NERFINISHED ⓘ |
| catalyzesReaction | NADPH + H+ + 2 ferricytochrome P450 → NADP+ + 2 ferrocytochrome P450 ⓘ |
| electronTransferPathway | NADPH to FAD to FMN to cytochrome P450 heme iron ⓘ |
| enablesProcess |
biosynthesis of endogenous compounds
ⓘ
drug metabolism ⓘ |
| foundIn | endoplasmic reticulum membrane ⓘ |
| hasAlternativeName |
CPR
NERFINISHED
ⓘ
NADPH–cytochrome P450 oxidoreductase NERFINISHED ⓘ P450 oxidoreductase NERFINISHED ⓘ |
| hasCofactor |
FAD
ⓘ
FMN ⓘ |
| hasDomain |
FAD-binding domain
ⓘ
FMN-binding domain ⓘ NADPH-binding domain ⓘ |
| hasECNumber | 1.6.2.4 ⓘ |
| hasSubcellularLocation | microsomes ⓘ |
| interactsWith |
cytochrome b5
ⓘ
microsomal cytochrome P450 enzymes ⓘ |
| isConservedIn |
many invertebrates
ⓘ
vertebrates ⓘ |
| isEncodedBy | POR gene NERFINISHED ⓘ |
| isEssentialFor | microsomal P450 catalytic cycle ⓘ |
| isImportantIn |
hepatic drug metabolism
ⓘ
metabolism of environmental chemicals ⓘ |
| isMembraneBound | true ⓘ |
| isRateLimitingFor | some cytochrome P450-mediated reactions ⓘ |
| isTargetOf | pharmacogenetic studies ⓘ |
| localization | cytosolic side of endoplasmic reticulum ⓘ |
| mutationAssociatedWith |
Antley–Bixler syndrome (POR-related)
NERFINISHED
ⓘ
POR deficiency ⓘ disorders of steroidogenesis ⓘ |
| participatesIn |
cholesterol metabolism
ⓘ
fatty acid metabolism ⓘ steroid biosynthesis ⓘ xenobiotic metabolism ⓘ |
| presentIn |
humans
ⓘ
mammals ⓘ many eukaryotes ⓘ |
| requires |
NADPH as electron donor
ⓘ
flavin adenine dinucleotide ⓘ flavin mononucleotide ⓘ |
| transfersElectronsTo | cytochrome P450 enzymes ⓘ |
| usesCofactor | NADPH ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.