P-glycoprotein

E241382

ABC transporter ATP-dependent efflux transporter protein drug transporter membrane protein multidrug resistance protein xenobiotic transporter

P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.

Try in SPARQL Jump to: Surface forms Statements Referenced by

All labels observed (5)

Label	Occurrences
P-glycoprotein canonical	3
ABCB1 gene	1
MDR1 protein	1
P-gp	1
multidrug resistance protein 1	1

Statements (55)

Predicate	Object
instanceOf	ABC transporter ⓘ ATP-dependent efflux transporter protein ⓘ drug transporter ⓘ membrane protein ⓘ multidrug resistance protein ⓘ xenobiotic transporter ⓘ
affectsPharmacokineticsProcess	brain penetration of drugs ⓘ drug absorption ⓘ drug distribution ⓘ drug elimination ⓘ oral bioavailability of drugs ⓘ
alsoKnownAs	P-glycoprotein ⓘ surface form: MDR1 protein P-glycoprotein ⓘ surface form: P-gp Pgp ⓘ P-glycoprotein ⓘ surface form: multidrug resistance protein 1
associatedWith	drug–drug interactions ⓘ interindividual variability in drug response ⓘ multidrug resistance in cancer chemotherapy ⓘ reduced intracellular drug accumulation ⓘ
belongsToFamily	ATP-binding cassette transporter family ⓘ
belongsToSubfamily	ABC subfamily B ⓘ
biologicalProcess	drug efflux ⓘ multidrug resistance ⓘ protection of tissues from xenobiotics ⓘ xenobiotic efflux ⓘ
cellularLocation	apical membrane of epithelial cells ⓘ plasma membrane ⓘ
conservedIn	many mammalian species ⓘ
encodedBy	P-glycoprotein self-linksurface differs ⓘ surface form: ABCB1 gene
foundInTissue	blood–brain barrier endothelial cells ⓘ hematopoietic cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental trophoblasts ⓘ
geneticVariationEffect	polymorphisms can alter expression or function ⓘ
hasMolecularFunction	ATPase activity ⓘ drug efflux transporter activity ⓘ xenobiotic-transporting ATPase activity ⓘ
inhibitorOfType	cyclosporine A ⓘ ketoconazole ⓘ quinidine ⓘ verapamil ⓘ
localRole	limits drug entry into the central nervous system ⓘ limits fetal exposure to xenobiotics at the placenta ⓘ promotes biliary excretion of drugs ⓘ promotes renal tubular secretion of drugs ⓘ
organism	Homo sapiens ⓘ
substrateOfType	HIV protease inhibitors ⓘ cardiac glycosides such as digoxin ⓘ immunosuppressants such as cyclosporine ⓘ many chemotherapeutic agents ⓘ various antibiotics ⓘ
transportMechanism	primary active transport ⓘ
usesEnergySource	ATP hydrolysis ⓘ

Referenced by (7)

Full triples — surface form annotated when it differs from this entity's canonical label.

Xarelto → isSubstrateOf → P-glycoprotein ⓘ

P-glycoprotein → alsoKnownAs → P-glycoprotein ⓘ

this entity surface form: P-gp

P-glycoprotein → alsoKnownAs → P-glycoprotein ⓘ

this entity surface form: MDR1 protein

P-glycoprotein → alsoKnownAs → P-glycoprotein ⓘ

this entity surface form: multidrug resistance protein 1

P-glycoprotein → encodedBy → P-glycoprotein self-linksurface differs ⓘ

this entity surface form: ABCB1 gene

apixaban → substrateOf → P-glycoprotein ⓘ

dabigatran → isSubstrateOf → P-glycoprotein ⓘ