ABC subfamily B
E852337
ABC subfamily B is a group of ATP-binding cassette (ABC) transporters that typically function as membrane proteins involved in the translocation of various molecules across cellular membranes and often contribute to multidrug resistance.
Statements (40)
| Predicate | Object |
|---|---|
| instanceOf |
ATP-binding cassette transporter subfamily
ⓘ
membrane protein family ⓘ protein family ⓘ |
| associatedWith |
chemotherapeutic drug resistance
ⓘ
multidrug resistance ⓘ xenobiotic efflux ⓘ |
| belongsTo | ABC transporter family ⓘ |
| hasAbbreviation | ABCB subfamily ⓘ |
| hasBiologicalProcess |
cellular response to drug
ⓘ
detoxification ⓘ transmembrane transport ⓘ |
| hasCharacteristic |
contain nucleotide-binding domains
ⓘ
contain transmembrane domains ⓘ multispan transmembrane proteins ⓘ |
| hasDomain |
nucleotide-binding domain
ⓘ
transmembrane helix domain ⓘ |
| hasFunction |
ATP-dependent transmembrane transport
ⓘ
bile acid transport ⓘ drug efflux ⓘ lipid transport ⓘ translocation of molecules across cellular membranes ⓘ |
| hasMember |
ABCB1
ⓘ
ABCB11 ⓘ ABCB4 NERFINISHED ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
ATPase activity ⓘ transmembrane transporter activity ⓘ |
| hasRoleIn |
cellular homeostasis
ⓘ
pharmacokinetics of drugs ⓘ protection against toxic compounds ⓘ |
| locatedIn |
cell membrane
ⓘ
intracellular membranes ⓘ plasma membrane ⓘ |
| partOf | ATP-binding cassette transporter superfamily ⓘ |
| transports |
bile salts
ⓘ
drugs ⓘ endogenous metabolites ⓘ lipids ⓘ xenobiotics ⓘ |
| usesEnergySource | ATP hydrolysis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.