cyclosporine A
E852338
Cyclosporine A is an immunosuppressant drug widely used to prevent organ transplant rejection and treat certain autoimmune diseases.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Cyclosporine A | 0 |
Statements (67)
| Predicate | Object |
|---|---|
| instanceOf |
calcineurin inhibitor
ⓘ
cyclic peptide ⓘ immunosuppressive drug ⓘ systemic immunosuppressant ⓘ |
| affectsPathway | T-cell receptor signaling pathway ⓘ |
| approvedForUseIn | 1983 ⓘ |
| belongsTo | World Health Organization List of Essential Medicines NERFINISHED ⓘ |
| bindsTo | cyclophilin ⓘ |
| commonAdverseEffect |
gingival hyperplasia
ⓘ
hirsutism ⓘ hyperlipidemia ⓘ hypertension ⓘ hyperuricemia ⓘ nephrotoxicity ⓘ tremor ⓘ |
| contraindicatedIn |
malignancy
ⓘ
uncontrolled hypertension ⓘ |
| decreases |
T-cell proliferation
ⓘ
interleukin-2 production ⓘ |
| developedBy | Sandoz NERFINISHED ⓘ |
| discoveredFrom | fungus Tolypocladium inflatum ⓘ |
| discoveredIn | 1970 ⓘ |
| drugInteractionWith |
CYP3A4 inducers
ⓘ
CYP3A4 inhibitors ⓘ grapefruit juice ⓘ nephrotoxic drugs ⓘ |
| hasATCCode |
D11AX14
ⓘ
L04AD01 ⓘ S01XA18 ⓘ |
| hasBioavailability | 20–50% ⓘ |
| hasBlackBoxWarning |
risk of malignancies
ⓘ
risk of serious infections ⓘ |
| hasBrandName |
Neoral
NERFINISHED
ⓘ
Restasis NERFINISHED ⓘ Sandimmune NERFINISHED ⓘ |
| hasCASNumber | 59865-13-3 ⓘ |
| hasChemicalFormula | C62H111N11O12 ⓘ |
| hasEliminationHalfLife | about 8.4 hours (variable) ⓘ |
| hasExcretion |
biliary
ⓘ
fecal ⓘ |
| hasMetabolism | hepatic ⓘ |
| hasMolecularWeight | 1202.61 g/mol ⓘ |
| hasPregnancyCategory | C (US, systemic) ⓘ |
| hasProteinBinding | >90% ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
ophthalmic ⓘ oral ⓘ topical ⓘ |
| hasUNIID | 83HN0GTJ6D ⓘ |
| isAdministeredAs | microemulsion formulation ⓘ |
| isChirality | chiral ⓘ |
| isListedAs | narrow therapeutic index drug ⓘ |
| mechanismOfAction |
inhibition of T-lymphocyte activation
ⓘ
inhibition of calcineurin ⓘ |
| metabolizedBy |
CYP3A4
NERFINISHED
ⓘ
CYP3A5 NERFINISHED ⓘ |
| targets | calcineurin NERFINISHED ⓘ |
| usedFor |
prevention of heart transplant rejection
ⓘ
prevention of kidney transplant rejection ⓘ prevention of liver transplant rejection ⓘ prevention of organ transplant rejection ⓘ treatment of atopic dermatitis ⓘ treatment of dry eye disease ⓘ treatment of nephrotic syndrome ⓘ treatment of psoriasis ⓘ treatment of rheumatoid arthritis ⓘ treatment of uveitis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.