quinidine
E852339
antiarrhythmic agent
class IA antiarrhythmic
pharmaceutical drug
quinoline alkaloid
stereoisomer of quinine
Quinidine is an antiarrhythmic medication derived from cinchona bark, primarily used to treat certain types of cardiac arrhythmias.
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
antiarrhythmic agent
ⓘ
class IA antiarrhythmic ⓘ pharmaceutical drug ⓘ quinoline alkaloid ⓘ stereoisomer of quinine ⓘ |
| belongsTo | World Health Organization list of essential medicines (historically for arrhythmias) NERFINISHED ⓘ |
| bindsTo | cardiac sodium channels ⓘ |
| derivedFrom | cinchona bark ⓘ |
| discoveredFrom | Cinchona species ⓘ |
| excretedBy | kidney ⓘ |
| hasAdverseEffect |
QT prolongation
ⓘ
cinchonism ⓘ diarrhea ⓘ headache ⓘ hemolytic anemia ⓘ hypotension ⓘ nausea ⓘ thrombocytopenia ⓘ tinnitus ⓘ torsades de pointes ⓘ ventricular tachycardia ⓘ |
| hasATCCode | C01BA01 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasCASNumber | 56-54-2 ⓘ |
| hasChEBIID | CHEBI:8639 ⓘ |
| hasChemicalFormula | C20H24N2O2 ⓘ |
| hasContraindication |
complete heart block
ⓘ
history of torsades de pointes ⓘ myasthenia gravis NERFINISHED ⓘ |
| hasDrugBankID | DB00908 ⓘ |
| hasHalfLife | approximately 6 to 8 hours ⓘ |
| hasIUPACName | (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol ⓘ |
| hasMolarMass | 324.42 g/mol ⓘ |
| hasPharmacologicalEffect |
decreases myocardial excitability
ⓘ
slows conduction in the His-Purkinje system ⓘ |
| hasPregnancyCategory | varies by jurisdiction ⓘ |
| hasPubChemCID | 441074 ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasUNII | ITX08688JL ⓘ |
| inhibits |
CYP2D6
ⓘ
P-glycoprotein NERFINISHED ⓘ |
| isOpticalIsomerOf | quinine ⓘ |
| mechanismOfAction |
blocks fast inward sodium current in cardiac tissue
ⓘ
prolongs QT interval ⓘ prolongs cardiac action potential duration ⓘ |
| metabolizedBy |
CYP2D6
NERFINISHED
ⓘ
CYP3A4 NERFINISHED ⓘ |
| usedFor |
pharmacologic cardioversion of atrial fibrillation
ⓘ
treatment of atrial fibrillation ⓘ treatment of atrial flutter ⓘ treatment of supraventricular arrhythmias ⓘ treatment of ventricular arrhythmias ⓘ |
| usedWith | digoxin NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.