Pgp
E852336
Pgp is a membrane transport protein that functions as an ATP-dependent efflux pump, playing a key role in multidrug resistance by exporting various drugs and xenobiotics out of cells.
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
ABC transporter
ⓘ
ATP-dependent efflux pump ⓘ membrane transport protein ⓘ multidrug resistance protein ⓘ |
| affectsPharmacokineticsOf | many clinically used drugs ⓘ |
| alsoKnownAs |
ABCB1
NERFINISHED
ⓘ
MDR1 NERFINISHED ⓘ P-gp NERFINISHED ⓘ Pgp NERFINISHED ⓘ |
| associatedWith |
chemotherapy failure in cancer
ⓘ
drug–drug interactions ⓘ |
| belongsToFamily | ATP-binding cassette transporter family NERFINISHED ⓘ |
| confersResistanceTo |
antibiotics
ⓘ
anticancer drugs ⓘ antiviral drugs ⓘ cardiac glycosides ⓘ immunosuppressive drugs ⓘ |
| encodedByGene | ABCB1 NERFINISHED ⓘ |
| foundInOrganism |
Homo sapiens
NERFINISHED
ⓘ
many mammalian species ⓘ |
| fullName | P-glycoprotein NERFINISHED ⓘ |
| hasDomain |
two nucleotide-binding domains
ⓘ
two transmembrane domains ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
ATP-dependent xenobiotic efflux ⓘ ATPase activity coupled to transmembrane movement of substances ⓘ drug transmembrane transporter activity ⓘ |
| hasSubstrate |
HIV protease inhibitors
ⓘ
cyclosporine A ⓘ digoxin ⓘ doxorubicin ⓘ many hydrophobic xenobiotics ⓘ paclitaxel ⓘ vinblastine ⓘ vincristine ⓘ |
| inhibitedBy |
cyclosporine A
NERFINISHED
ⓘ
elacridar NERFINISHED ⓘ tariquidar NERFINISHED ⓘ verapamil NERFINISHED ⓘ |
| locatedIn |
apical membrane of epithelial cells
ⓘ
blood–brain barrier endothelial cells ⓘ hematopoietic cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental trophoblasts ⓘ plasma membrane ⓘ |
| participatesIn |
biliary excretion of drugs
ⓘ
blood–brain barrier function ⓘ drug efflux ⓘ limitation of oral drug absorption ⓘ multidrug resistance ⓘ protection of tissues from toxic xenobiotics ⓘ renal excretion of drugs ⓘ xenobiotic transport ⓘ |
| transportDirection | from intracellular space to extracellular space ⓘ |
| usesEnergySource | ATP hydrolysis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.