CD4+ T cells
E228561
CD4+ T cells are a subset of immune cells that coordinate and regulate the body’s adaptive immune response, playing a central role in defending against infections.
All labels observed (3)
| Label | Occurrences |
|---|---|
| CD4+ T cells canonical | 1 |
| T helper 2 cells | 1 |
| T helper cells | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2062858 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD4+ T cells Context triple: [HIV/AIDS, targetsCellType, CD4+ T cells]
-
A.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
B.
ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
-
C.
CDT
CDT is the daylight saving time observed in the Central Time Zone of North America, typically six hours behind Coordinated Universal Time (UTC−5).
-
D.
C-3a
C-3a is a commuter rail line within the Cercanías Madrid network serving suburban areas around Spain’s capital.
-
E.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD4+ T cells Target entity description: CD4+ T cells are a subset of immune cells that coordinate and regulate the body’s adaptive immune response, playing a central role in defending against infections.
-
A.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
B.
ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
-
C.
CDT
CDT is the daylight saving time observed in the Central Time Zone of North America, typically six hours behind Coordinated Universal Time (UTC−5).
-
D.
C-3a
C-3a is a commuter rail line within the Cercanías Madrid network serving suburban areas around Spain’s capital.
-
E.
Leqembi
Leqembi is an Alzheimer’s disease drug (lecanemab) that targets amyloid-beta plaques to slow cognitive decline in early-stage patients.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
T lymphocyte subset
ⓘ
adaptive immune cell ⓘ white blood cell ⓘ |
| areActivatedBy |
B cells
ⓘ
antigen-presenting cells ⓘ dendritic cells ⓘ macrophages ⓘ |
| areDepletedIn |
HIV/AIDS
ⓘ
surface form:
AIDS
|
| areTargetedBy |
HIV-1
ⓘ
surface form:
HIV
|
| canBecome |
effector T cells
ⓘ
memory T cells ⓘ |
| canBeDysregulatedIn |
allergic diseases
ⓘ
autoimmune diseases ⓘ |
| canBeTargetOf | immunotherapies ⓘ |
| developIn | thymus ⓘ |
| differentiateFrom | common lymphoid progenitors ⓘ |
| differentiateInto |
T follicular helper cells
ⓘ
T helper 1 cells ⓘ T helper 17 cells ⓘ CD4+ T cells self-linksurface differs ⓘ
surface form:
T helper 2 cells
regulatory T cells ⓘ |
| express |
CD3 complex
ⓘ
MHC class II coreceptor ⓘ T cell receptor ⓘ |
| function |
coordinate adaptive immune responses
ⓘ
provide help to B cells ⓘ provide help to CD8+ T cells ⓘ regulate immune responses ⓘ secrete cytokines ⓘ |
| hasMarker | CD4 ⓘ |
| highCD4CountAssociatedWith | better immune function ⓘ |
| lacksMarker | CD8 ⓘ |
| locatedIn |
blood
ⓘ
lymph nodes ⓘ mucosal tissues ⓘ spleen ⓘ |
| lowCD4CountAssociatedWith | immunodeficiency ⓘ |
| measuredBy | CD4 count ⓘ |
| originateFrom | hematopoietic stem cells ⓘ |
| playRoleIn |
anti-parasitic immunity
ⓘ
antibacterial immunity ⓘ antifungal immunity ⓘ antiviral immunity ⓘ defense against infections ⓘ immunological memory ⓘ vaccine responses ⓘ |
| recognizeAntigenPresentedBy | MHC class II molecules ⓘ |
| subsetOf |
T cells
ⓘ
lymphocytes ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD4+ T cells Description of subject: CD4+ T cells are a subset of immune cells that coordinate and regulate the body’s adaptive immune response, playing a central role in defending against infections.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
T helper 2 cells
this entity surface form:
T helper cells