CD3 complex
E802043
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
T-cell surface receptor component
ⓘ
protein complex ⓘ |
| abbreviatedAs | CD3 NERFINISHED ⓘ |
| associatedWith | T-cell receptor ⓘ |
| associatedWithDisease |
T-cell immunodeficiency
ⓘ
severe combined immunodeficiency when mutated ⓘ |
| binds |
T-cell receptor alpha chain
ⓘ
T-cell receptor beta chain ⓘ |
| containsMotif | immunoreceptor tyrosine-based activation motif ⓘ |
| encodedBy |
CD247 gene
NERFINISHED
ⓘ
CD3D gene NERFINISHED ⓘ CD3E gene NERFINISHED ⓘ CD3G gene NERFINISHED ⓘ |
| essentialFor |
T-cell activation
ⓘ
T-cell signal transduction ⓘ |
| expressedOn |
mature T cells
ⓘ
most NKT cells ⓘ thymocytes ⓘ |
| hasComponentType | type I transmembrane protein ⓘ |
| hasCytoplasmicDomainFunction | signal transduction ⓘ |
| hasSubunit |
CD3γ chain
NERFINISHED
ⓘ
CD3δ chain NERFINISHED ⓘ CD3ε chain NERFINISHED ⓘ CD3ζ chain ⓘ CD3η chain ⓘ |
| hasTopology |
cytoplasmic tail with ITAMs
ⓘ
extracellular immunoglobulin-like domain ⓘ single transmembrane helix ⓘ |
| involvedIn |
T-cell receptor signaling pathway
NERFINISHED
ⓘ
T-cell selection in thymus ⓘ adaptive immune response ⓘ thymocyte development ⓘ |
| locatedIn | plasma membrane of T cells ⓘ |
| orthologFoundIn |
human
ⓘ
mouse ⓘ rat ⓘ |
| partOf | T-cell receptor–CD3 complex NERFINISHED ⓘ |
| phosphorylatedBy | Src family kinases Lck and Fyn NERFINISHED ⓘ |
| playsRoleIn |
T-cell proliferation
ⓘ
antigen-specific T-cell responses ⓘ cytokine production by T cells ⓘ |
| recognizedBy | anti-CD3 monoclonal antibodies ⓘ |
| recruits | ZAP-70 tyrosine kinase NERFINISHED ⓘ |
| requiredFor |
T-cell receptor internalization
ⓘ
surface expression of T-cell receptor ⓘ |
| targetOf | OKT3 antibody ⓘ |
| usedAsMarkerFor | T lymphocytes NERFINISHED ⓘ |
| usedIn |
flow cytometry for T-cell enumeration
ⓘ
immunohistochemistry for T-cell identification ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.