HIV-1
E719039
HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
All labels observed (3)
| Label | Occurrences |
|---|---|
| HIV | 3 |
| HIV-1 canonical | 1 |
| HIV-1 reverse transcriptase | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T8218321 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
Target entity: HIV-1 Context triple: [Luc Montagnier, coDiscovered, HIV-1]
-
A.
HIV/AIDS
HIV/AIDS is a chronic, life-threatening disease caused by the human immunodeficiency virus, which attacks the immune system and has had profound global public health, social, and political impacts since its emergence in the late 20th century.
-
B.
Vircava
Vircava is a river in Latvia that serves as one of the tributaries feeding into the larger Lielupe River system.
-
C.
Ebolavirus
Ebolavirus is a genus of filamentous, enveloped RNA viruses in the Filoviridae family that cause severe and often fatal hemorrhagic fever in humans and other primates.
-
D.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
E.
Zaire ebolavirus
Zaire ebolavirus is a highly virulent species of Ebola virus responsible for severe hemorrhagic fever outbreaks in humans, including the major 2014–2016 epidemic in West Africa.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
Target entity: HIV-1 Target entity description: HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
-
A.
HIV/AIDS
HIV/AIDS is a chronic, life-threatening disease caused by the human immunodeficiency virus, which attacks the immune system and has had profound global public health, social, and political impacts since its emergence in the late 20th century.
-
B.
Vircava
Vircava is a river in Latvia that serves as one of the tributaries feeding into the larger Lielupe River system.
-
C.
Ebolavirus
Ebolavirus is a genus of filamentous, enveloped RNA viruses in the Filoviridae family that cause severe and often fatal hemorrhagic fever in humans and other primates.
-
D.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
E.
Zaire ebolavirus
Zaire ebolavirus is a highly virulent species of Ebola virus responsible for severe hemorrhagic fever outbreaks in humans, including the major 2014–2016 epidemic in West Africa.
- F. None of above. chosen
Statements (97)
| Predicate | Object |
|---|---|
| instanceOf |
RNA virus
ⓘ
human pathogen ⓘ lentivirus ⓘ retrovirus ⓘ |
| biosafetyLevel | BSL-3 pathogen ⓘ |
| causes |
AIDS
ⓘ
HIV infection ⓘ |
| diagnosedBy |
HIV RNA PCR tests
NERFINISHED
ⓘ
HIV antibody tests ⓘ HIV antigen tests ⓘ |
| drugTarget |
entry receptors
ⓘ
integrase ⓘ protease ⓘ reverse transcriptase ⓘ |
| encodesProtein |
Env glycoprotein gp160
ⓘ
Gag polyprotein NERFINISHED ⓘ Nef protein NERFINISHED ⓘ Pol polyprotein ⓘ Rev protein NERFINISHED ⓘ Tat protein NERFINISHED ⓘ Vif protein NERFINISHED ⓘ Vpr protein NERFINISHED ⓘ Vpu protein NERFINISHED ⓘ gp120 ⓘ gp41 NERFINISHED ⓘ integrase ⓘ protease ⓘ reverse transcriptase ⓘ |
| entryMechanism | fusion with host cell membrane ⓘ |
| family | Retroviridae NERFINISHED ⓘ |
| firstIsolatedBy | Luc Montagnier’s team at the Pasteur Institute NERFINISHED ⓘ |
| firstRecognized | early 1980s ⓘ |
| genomeLength | approximately 9.7 kilobases ⓘ |
| genomeSegmentation | non-segmented ⓘ |
| genomeType | single-stranded positive-sense RNA ⓘ |
| genus | Lentivirus NERFINISHED ⓘ |
| groupMHasSubtype |
A
ⓘ
B ⓘ C ⓘ D ⓘ F ⓘ G ⓘ H ⓘ J ⓘ K ⓘ |
| hasEnzymeActivity |
integrase activity
ⓘ
protease activity ⓘ reverse transcriptase activity ⓘ |
| hasGene |
env
ⓘ
gag ⓘ nef ⓘ pol ⓘ rev ⓘ tat ⓘ vif ⓘ vpr ⓘ vpu ⓘ |
| hasGroup |
M
ⓘ
N ⓘ O ⓘ P ⓘ |
| hasProperty |
causes progressive immune deficiency
ⓘ
establishes latent infection ⓘ high genetic variability ⓘ high mutation rate ⓘ |
| hasStructure |
conical capsid
ⓘ
enveloped virion ⓘ |
| host | Homo sapiens NERFINISHED ⓘ |
| immuneSystemEffect |
depletion of CD4+ T cells
ⓘ
impairment of cell-mediated immunity ⓘ |
| integrationTarget | host genome DNA ⓘ |
| majorPandemicGroup | group M ⓘ |
| notTransmittedBy |
airborne route
ⓘ
casual contact ⓘ insect bites ⓘ |
| order | Ortervirales NERFINISHED ⓘ |
| parentTaxon |
Human immunodeficiency virus
NERFINISHED
ⓘ
Lentivirus NERFINISHED ⓘ Orthoretrovirinae NERFINISHED ⓘ Retroviridae NERFINISHED ⓘ |
| primaryCauseOf | global HIV/AIDS pandemic ⓘ |
| replicationSite |
host cell cytoplasm
ⓘ
host cell nucleus ⓘ |
| subtypeOf | HIV NERFINISHED ⓘ |
| targetsCellType |
CD4+ T cell
ⓘ
dendritic cell ⓘ macrophage ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
blood exposure
ⓘ
mother-to-child transmission ⓘ sexual contact ⓘ sharing of contaminated needles ⓘ |
| treatment | antiretroviral therapy ⓘ |
| usesCoreceptor |
CCR5
NERFINISHED
ⓘ
CXCR4 NERFINISHED ⓘ |
| usesReceptor | CD4 NERFINISHED ⓘ |
| zoonoticOrigin | chimpanzee SIVcpz ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Subject: HIV-1 Description of subject: HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.