HIV-1
E719039
HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
Observed surface forms (2)
| Surface form | Occurrences |
|---|---|
| HIV | 3 |
| HIV-1 reverse transcriptase | 1 |
Statements (97)
| Predicate | Object |
|---|---|
| instanceOf |
RNA virus
ⓘ
human pathogen ⓘ lentivirus ⓘ retrovirus ⓘ |
| biosafetyLevel | BSL-3 pathogen ⓘ |
| causes |
AIDS
ⓘ
HIV infection ⓘ |
| diagnosedBy |
HIV RNA PCR tests
NERFINISHED
ⓘ
HIV antibody tests ⓘ HIV antigen tests ⓘ |
| drugTarget |
entry receptors
ⓘ
integrase ⓘ protease ⓘ reverse transcriptase ⓘ |
| encodesProtein |
Env glycoprotein gp160
ⓘ
Gag polyprotein NERFINISHED ⓘ Nef protein NERFINISHED ⓘ Pol polyprotein ⓘ Rev protein NERFINISHED ⓘ Tat protein NERFINISHED ⓘ Vif protein NERFINISHED ⓘ Vpr protein NERFINISHED ⓘ Vpu protein NERFINISHED ⓘ gp120 ⓘ gp41 NERFINISHED ⓘ integrase ⓘ protease ⓘ reverse transcriptase ⓘ |
| entryMechanism | fusion with host cell membrane ⓘ |
| family | Retroviridae NERFINISHED ⓘ |
| firstIsolatedBy | Luc Montagnier’s team at the Pasteur Institute NERFINISHED ⓘ |
| firstRecognized | early 1980s ⓘ |
| genomeLength | approximately 9.7 kilobases ⓘ |
| genomeSegmentation | non-segmented ⓘ |
| genomeType | single-stranded positive-sense RNA ⓘ |
| genus | Lentivirus NERFINISHED ⓘ |
| groupMHasSubtype |
A
ⓘ
B ⓘ C ⓘ D ⓘ F ⓘ G ⓘ H ⓘ J ⓘ K ⓘ |
| hasEnzymeActivity |
integrase activity
ⓘ
protease activity ⓘ reverse transcriptase activity ⓘ |
| hasGene |
env
ⓘ
gag ⓘ nef ⓘ pol ⓘ rev ⓘ tat ⓘ vif ⓘ vpr ⓘ vpu ⓘ |
| hasGroup |
M
ⓘ
N ⓘ O ⓘ P ⓘ |
| hasProperty |
causes progressive immune deficiency
ⓘ
establishes latent infection ⓘ high genetic variability ⓘ high mutation rate ⓘ |
| hasStructure |
conical capsid
ⓘ
enveloped virion ⓘ |
| host | Homo sapiens NERFINISHED ⓘ |
| immuneSystemEffect |
depletion of CD4+ T cells
ⓘ
impairment of cell-mediated immunity ⓘ |
| integrationTarget | host genome DNA ⓘ |
| majorPandemicGroup | group M ⓘ |
| notTransmittedBy |
airborne route
ⓘ
casual contact ⓘ insect bites ⓘ |
| order | Ortervirales NERFINISHED ⓘ |
| parentTaxon |
Human immunodeficiency virus
NERFINISHED
ⓘ
Lentivirus NERFINISHED ⓘ Orthoretrovirinae NERFINISHED ⓘ Retroviridae NERFINISHED ⓘ |
| primaryCauseOf | global HIV/AIDS pandemic ⓘ |
| replicationSite |
host cell cytoplasm
ⓘ
host cell nucleus ⓘ |
| subtypeOf | HIV NERFINISHED ⓘ |
| targetsCellType |
CD4+ T cell
ⓘ
dendritic cell ⓘ macrophage ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
blood exposure
ⓘ
mother-to-child transmission ⓘ sexual contact ⓘ sharing of contaminated needles ⓘ |
| treatment | antiretroviral therapy ⓘ |
| usesCoreceptor |
CCR5
NERFINISHED
ⓘ
CXCR4 NERFINISHED ⓘ |
| usesReceptor | CD4 NERFINISHED ⓘ |
| zoonoticOrigin | chimpanzee SIVcpz ⓘ |
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
HIV
subject surface form:
human adenovirus serotype 26
this entity surface form:
HIV
this entity surface form:
HIV