Truvada

E409694

HIV medication antiretroviral medication brand-name drug fixed-dose combination drug

Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.

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All labels observed (2)

Label	Occurrences
Truvada canonical	1
emtricitabine and tenofovir disoproxil fumarate	1

Statements (48)

Predicate	Object
instanceOf	HIV medication ⓘ antiretroviral medication ⓘ brand-name drug ⓘ fixed-dose combination drug ⓘ
approvedBy	Food and Drug Administration ⓘ surface form: U.S. Food and Drug Administration
ATCCode	J05AR02 ⓘ
boxedWarning	risk of acute exacerbations of hepatitis B after discontinuation ⓘ risk of lactic acidosis and severe hepatomegaly with steatosis ⓘ
commonSideEffect	diarrhea ⓘ headache ⓘ nausea ⓘ
containsDoseStrength	emtricitabine 200 mg ⓘ tenofovir disoproxil fumarate 300 mg ⓘ
contraindication	severe renal impairment ⓘ
developer	Gilead Sciences (board member) ⓘ surface form: Gilead Sciences
dosageForm	tablet ⓘ
drugClass	nucleoside reverse transcriptase inhibitor ⓘ nucleotide reverse transcriptase inhibitor ⓘ
FDAApprovalIndication	pre-exposure prophylaxis to reduce the risk of sexually acquired HIV-1 infection ⓘ treatment of HIV-1 infection in combination with other antiretrovirals ⓘ
FDAApprovalYear	2004 ⓘ
hasActiveIngredient	emtricitabine ⓘ tenofovir disoproxil fumarate ⓘ
hasGenericName	Truvada self-linksurface differs ⓘ surface form: emtricitabine and tenofovir disoproxil fumarate
hasPatentHolder	Gilead Sciences (board member) ⓘ surface form: Gilead Sciences
indication	post-exposure prophylaxis for HIV (off-label in some settings) ⓘ pre-exposure prophylaxis for HIV-1 (PrEP) ⓘ treatment of HIV-1 infection ⓘ
isGenericAvailable	true ⓘ
isNotEffectiveAgainst	established HIV infection when used alone ⓘ
isOnWHOEML	yes ⓘ
isUsedWith	other antiretroviral agents ⓘ
legalStatusEU	prescription-only ⓘ
legalStatusUS	prescription-only ⓘ
marketingAuthorizationHolder	Gilead Sciences (board member) ⓘ surface form: Gilead Sciences
pregnancyCategoryUS	B (historical classification) ⓘ
prevents	sexual transmission of HIV-1 when used as PrEP with adherence ⓘ
requiresCombinationForTreatment	yes ⓘ
requiresMonitoring	HIV status before and during PrEP ⓘ renal function ⓘ
routeOfAdministration	oral ⓘ
seriousSideEffect	decreased bone mineral density ⓘ renal impairment ⓘ
takenFrequency	once daily ⓘ
targets	HIV-1 ⓘ surface form: HIV-1 reverse transcriptase
usedForPopulation	adolescents at high risk of HIV infection (meeting weight and other criteria) ⓘ adults at high risk of HIV infection ⓘ
usedInProgram	HIV prevention programs worldwide ⓘ

Referenced by (2)

Full triples — surface form annotated when it differs from this entity's canonical label.

Gilead Sciences (board member) → product → Truvada ⓘ

subject surface form: Gilead Sciences

Truvada → hasGenericName → Truvada self-linksurface differs ⓘ

this entity surface form: emtricitabine and tenofovir disoproxil fumarate