hematopoietic stem cells
E802042
Hematopoietic stem cells are multipotent stem cells in the bone marrow that give rise to all blood and immune cell lineages throughout life.
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
adult stem cell
ⓘ
multipotent stem cell ⓘ somatic stem cell ⓘ stem cell ⓘ |
| canBeDamagedBy |
chemotherapy
ⓘ
ionizing radiation ⓘ |
| differentiationControlledBy |
transcription factor GATA-2
NERFINISHED
ⓘ
transcription factor RUNX1 NERFINISHED ⓘ transcription factor SCL/TAL1 NERFINISHED ⓘ |
| expresses |
CD117 (c-Kit)
NERFINISHED
ⓘ
CD34 (human, subset) NERFINISHED ⓘ CD90 (Thy-1) NERFINISHED ⓘ Sca-1 (mouse) NERFINISHED ⓘ |
| firstAppearIn | aorta-gonad-mesonephros region GENERATED ⓘ |
| foundIn |
birds
ⓘ
fish ⓘ mammals ⓘ reptiles ⓘ |
| givesRiseTo |
B lymphocytes
NERFINISHED
ⓘ
T lymphocytes NERFINISHED ⓘ dendritic cells ⓘ erythrocytes ⓘ granulocytes ⓘ lymphoid progenitor cells ⓘ megakaryocytes ⓘ monocytes ⓘ myeloid progenitor cells ⓘ natural killer cells ⓘ platelets ⓘ |
| hasProperty |
clonogenic potential
ⓘ
long-term repopulating ability ⓘ multipotency ⓘ quiescence ⓘ self-renewal capacity ⓘ |
| interactsWith |
endothelial cells
ⓘ
mesenchymal stromal cells ⓘ osteoblasts ⓘ |
| lacksExpressionOf | lineage markers (Lin−) ⓘ |
| locatedIn |
bone marrow
ⓘ
fetal liver ⓘ peripheral blood ⓘ spleen ⓘ thymus (early development) NERFINISHED ⓘ umbilical cord blood ⓘ |
| mobilizedBy |
G-CSF
NERFINISHED
ⓘ
plerixafor NERFINISHED ⓘ |
| originatesDuring | embryonic hematopoiesis ⓘ |
| playsRoleIn |
immune system maintenance
ⓘ
lifelong blood cell production ⓘ |
| regulatedBy |
CXCL12 (SDF-1)
NERFINISHED
ⓘ
TGF-beta NERFINISHED ⓘ interleukin-3 NERFINISHED ⓘ interleukin-6 ⓘ stem cell factor ⓘ thrombopoietin ⓘ |
| resideIn | bone marrow niche ⓘ |
| studiedUsing |
bone marrow transplantation assays
ⓘ
colony-forming unit assays ⓘ |
| usedFor |
bone marrow transplantation
ⓘ
hematopoietic stem cell transplantation ⓘ treatment of aplastic anemia ⓘ treatment of hemoglobinopathies ⓘ treatment of inherited immunodeficiencies ⓘ treatment of leukemia ⓘ treatment of lymphoma ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.