CD22
E902890
B-cell surface antigen
cell surface glycoprotein
immunoglobulin superfamily protein
inhibitory co-receptor
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
B-cell surface antigen
ⓘ
cell surface glycoprotein ⓘ immunoglobulin superfamily protein ⓘ inhibitory co-receptor ⓘ |
| alternativeName | Siglec-2 NERFINISHED ⓘ |
| associatedWithDisease |
B-cell non-Hodgkin lymphoma
NERFINISHED
ⓘ
acute lymphoblastic leukemia ⓘ chronic lymphocytic leukemia NERFINISHED ⓘ rheumatoid arthritis NERFINISHED ⓘ systemic lupus erythematosus ⓘ |
| bindsTo |
alpha-2,6-linked sialic acid
ⓘ
sialic acid–containing ligands ⓘ |
| cellularLocation |
B cell surface
ⓘ
plasma membrane ⓘ |
| encodedBy | CD22 gene NERFINISHED ⓘ |
| expressedOn |
B cells
ⓘ
mature B cells ⓘ peripheral B cells ⓘ |
| hasAbbreviation | ITIMs ⓘ |
| hasDomain |
cytoplasmic tail
ⓘ
extracellular domain ⓘ transmembrane domain ⓘ |
| hasFeature | immunoreceptor tyrosine-based inhibitory motifs ⓘ |
| involvedIn | endocytosis of bound antibodies or ligands ⓘ |
| ligandRecognizedOn |
glycolipids
ⓘ
glycoproteins ⓘ |
| locatedOnChromosome | human chromosome 19q13.1 ⓘ |
| memberOf |
CD antigen cluster
ⓘ
Siglec family NERFINISHED ⓘ |
| modulates | B cell receptor signaling ⓘ |
| negativelyRegulates |
B cell activation
ⓘ
B cell receptor signaling ⓘ |
| notExpressedOn |
NK cells
ⓘ
T cells ⓘ myeloid cells ⓘ |
| orthologFoundIn |
mouse
ⓘ
rat ⓘ |
| participatesIn |
maintenance of B cell tolerance
ⓘ
regulation of immune responses ⓘ |
| phosphorylatedBy |
Src family kinases
NERFINISHED
ⓘ
Syk kinase NERFINISHED ⓘ |
| recruits |
SHP-1 phosphatase
NERFINISHED
ⓘ
SHP-2 phosphatase NERFINISHED ⓘ |
| regulates | calcium signaling in B cells ⓘ |
| targetOf |
CAR T-cell therapies
NERFINISHED
ⓘ
antibody-drug conjugates ⓘ monoclonal antibodies ⓘ |
| usedAs |
diagnostic marker for B-cell malignancies
ⓘ
therapeutic target in B-cell malignancies ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.