Triple

Target class: inhibitory co-receptor
Context triple: [CD22, instanceOf, inhibitory co-receptor]

• A. immune checkpoint receptor chosen
  An immune checkpoint receptor is a cell-surface protein, typically on immune cells like T cells, that modulates immune responses by delivering inhibitory or stimulatory signals upon binding to its ligand, thereby maintaining self-tolerance and preventing overactivation.
• B. immune checkpoint ligand
  An immune checkpoint ligand is a molecule, typically expressed on the surface of cells, that binds to corresponding immune checkpoint receptors to modulate and often inhibit immune cell activation and maintain immune homeostasis.
• C. Bruton’s tyrosine kinase
  Bruton’s tyrosine kinase is a non-receptor tyrosine kinase crucial for B-cell receptor signaling, development, and function, and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
• D. transmembrane receptor
  A transmembrane receptor is a membrane-spanning protein that detects extracellular signals and transduces them into specific intracellular responses.
• E. Bruton tyrosine kinase inhibitor
  A Bruton tyrosine kinase inhibitor is a targeted small-molecule drug that blocks BTK signaling in B cells to disrupt pathways critical for their activation, proliferation, and survival, primarily used in the treatment of certain B-cell malignancies and autoimmune diseases.
• F. None of above.