PD-1
E822412
cell surface receptor
immune checkpoint receptor
inhibitory receptor
protein
type I membrane protein
PD-1 is an inhibitory immune checkpoint receptor on T cells that downregulates immune responses and is a key target of cancer immunotherapy.
Statements (64)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface receptor
ⓘ
immune checkpoint receptor ⓘ inhibitory receptor ⓘ protein ⓘ type I membrane protein ⓘ |
| associatedWith |
T cell exhaustion
ⓘ
chronic viral infection ⓘ tumor immune evasion ⓘ |
| belongsToFamily | CD28 family NERFINISHED ⓘ |
| binds |
PD-L1
NERFINISHED
ⓘ
PD-L2 NERFINISHED ⓘ |
| chromosomalLocationOfGene | 2q37.3 ⓘ |
| clinicalUseContext |
treatment of Hodgkin lymphoma
ⓘ
treatment of melanoma ⓘ treatment of non-small cell lung cancer ⓘ treatment of renal cell carcinoma ⓘ |
| containsMotif |
ITIM motif
ⓘ
ITSM motif ⓘ |
| cytoplasmicTailRecruits |
SHP-1 phosphatase
NERFINISHED
ⓘ
SHP-2 phosphatase NERFINISHED ⓘ |
| downregulates | immune responses ⓘ |
| encodedBy | PDCD1 gene NERFINISHED ⓘ |
| expressedOn |
B cells
ⓘ
T cells NERFINISHED ⓘ activated T cells ⓘ dendritic cells ⓘ exhausted T cells ⓘ monocytes ⓘ natural killer cells ⓘ |
| hasDomain | immunoglobulin V-like domain ⓘ |
| hasFullName | Programmed cell death protein 1 ⓘ |
| hasLigand |
PD-L1
NERFINISHED
ⓘ
PD-L2 NERFINISHED ⓘ |
| hasSynonym |
CD279
NERFINISHED
ⓘ
PDCD1 protein NERFINISHED ⓘ |
| inhibits |
CD28 costimulatory signaling
ⓘ
T cell receptor signaling ⓘ |
| involvedIn |
maintenance of self-tolerance
ⓘ
peripheral tolerance ⓘ prevention of autoimmunity ⓘ |
| isTargetOf |
anti-PD-1 monoclonal antibodies
ⓘ
cancer immunotherapy ⓘ immune checkpoint blockade ⓘ |
| isTargetOfDrug |
camrelizumab
NERFINISHED
ⓘ
cemiplimab NERFINISHED ⓘ nivolumab NERFINISHED ⓘ pembrolizumab NERFINISHED ⓘ sintilimab NERFINISHED ⓘ spartalizumab NERFINISHED ⓘ tislelizumab NERFINISHED ⓘ toripalimab NERFINISHED ⓘ |
| lengthInAminoAcids | 288 ⓘ |
| locatedIn | plasma membrane ⓘ |
| negativelyRegulates |
T cell activation
ⓘ
T cell effector function ⓘ T cell proliferation ⓘ cytokine production ⓘ |
| postTranslationalModification |
N-linked glycosylation
ⓘ
phosphorylation ⓘ |
| species | Homo sapiens NERFINISHED ⓘ |
| therapeuticArea |
autoimmune disease
ⓘ
oncology ⓘ |
| upregulatedIn |
chronic infection
ⓘ
tumor-infiltrating lymphocytes ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.