CDK6
E564269
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
cyclin-dependent kinase
ⓘ
human gene ⓘ protein kinase ⓘ |
| associatedWithDisease |
acute lymphoblastic leukemia
ⓘ
acute myeloid leukemia ⓘ breast cancer ⓘ glioblastoma ⓘ lymphoma ⓘ melanoma ⓘ non-small cell lung cancer NERFINISHED ⓘ |
| belongsToPathway |
G1/S DNA damage checkpoint pathway
NERFINISHED
ⓘ
cell cycle pathway ⓘ p16INK4A-CDK4/6-RB pathway NERFINISHED ⓘ |
| encodes | cyclin-dependent kinase 6 NERFINISHED ⓘ |
| hasAlternativeName |
CDKN6
ⓘ
cell division protein kinase 6 ⓘ |
| hasBiologicalProcess |
B cell proliferation
ⓘ
G1 phase of mitotic cell cycle ⓘ G1/S transition of mitotic cell cycle ⓘ T cell differentiation ⓘ cell cycle progression ⓘ hematopoietic cell differentiation ⓘ regulation of cell proliferation ⓘ |
| hasCellularComponent |
cytoplasm
ⓘ
nucleus ⓘ |
| hasEntrezGeneID | 1021 ⓘ |
| hasEnzymeCommissionNumber | EC 2.7.11.22 ⓘ |
| hasGeneSymbol | CDK6 NERFINISHED ⓘ |
| hasHGNCID | HGNC:1777 ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
cyclin-dependent protein serine/threonine kinase activity ⓘ protein serine/threonine kinase activity ⓘ |
| hasUniProtID | Q00534 ⓘ |
| inhibitedBy | CDK4/6 inhibitors ⓘ |
| interactsWith |
cyclin D1
ⓘ
cyclin D2 ⓘ cyclin D3 NERFINISHED ⓘ |
| isDrugTargetOf |
abemaciclib
NERFINISHED
ⓘ
dalpiciclib NERFINISHED ⓘ palbociclib NERFINISHED ⓘ ribociclib ⓘ trilaciclib NERFINISHED ⓘ |
| locatedOnChromosome | chromosome 7 ⓘ |
| locatedOnChromosomeBand | 7q21.2 ⓘ |
| organism | Homo sapiens ⓘ |
| phosphorylates |
RB1
NERFINISHED
ⓘ
retinoblastoma protein ⓘ |
| regulatedBy |
CDKN2A
NERFINISHED
ⓘ
CDKN2B NERFINISHED ⓘ p15INK4B NERFINISHED ⓘ p16INK4A NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.