glycinamide ribonucleotide formyltransferase
E561031
Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
formyltransferase ⓘ transferase ⓘ |
| associatedWith |
DNA synthesis
ⓘ
RNA synthesis ⓘ cell proliferation ⓘ |
| belongsToPathway | one-carbon metabolism via folate ⓘ |
| biologicalProcess |
nucleotide biosynthetic process
ⓘ
purine-containing compound biosynthetic process ⓘ |
| catalyzesReaction | formylation of glycinamide ribonucleotide to formylglycinamide ribonucleotide ⓘ |
| cellularLocation | cytosol ⓘ |
| dependsOn | availability of folate derivatives ⓘ |
| ECNumber | 2.1.2.2 ⓘ |
| essentialFor |
ATP biosynthesis
ⓘ
GTP biosynthesis ⓘ purine nucleotide biosynthesis ⓘ |
| foundIn |
animals
ⓘ
bacteria ⓘ humans ⓘ plants ⓘ yeast ⓘ |
| geneSymbolInHuman | GART NERFINISHED ⓘ |
| inhibitedBy | antifolate inhibitors of de novo purine synthesis ⓘ |
| isDomainOf | phosphoribosylglycinamide formyltransferase / phosphoribosylglycinamide synthetase / phosphoribosylaminoimidazole synthetase ⓘ |
| isPartOf | trifunctional GART protein in humans ⓘ |
| isRateLimitingIn | certain steps of de novo purine biosynthesis ⓘ |
| isStepOf | multistep pathway from phosphoribosyl pyrophosphate to inosine monophosphate ⓘ |
| isTargetIn | antimetabolite chemotherapy strategies ⓘ |
| molecularFunction |
glycinamide ribonucleotide formyltransferase activity
ⓘ
one-carbon group transfer ⓘ |
| orthologIn |
Arabidopsis thaliana
NERFINISHED
ⓘ
Escherichia coli NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ Saccharomyces cerevisiae NERFINISHED ⓘ |
| participatesIn |
IMP biosynthetic process
ⓘ
de novo purine biosynthesis ⓘ |
| produces | formylglycinamide ribonucleotide ⓘ |
| product |
formylglycinamide ribonucleotide
ⓘ
tetrahydrofolate ⓘ |
| requires | folate metabolism ⓘ |
| substrate |
10-formyltetrahydrofolate
ⓘ
glycinamide ribonucleotide ⓘ |
| targetOf |
antifolate drugs
ⓘ
certain anticancer drugs ⓘ |
| usesCofactor | 10-formyltetrahydrofolate ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.