Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
E299919
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc are a set of transcription factors whose forced expression can reprogram differentiated somatic cells into induced pluripotent stem cells.
All labels observed (3)
| Label | Occurrences |
|---|---|
| Klf4 | 1 |
| Oct3/4 maintains pluripotency | 1 |
| Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2800020 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc Context triple: [Shinya Yamanaka, notableConcept, Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc]
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A.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
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B.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
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C.
Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
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D.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
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E.
The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc Target entity description: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc are a set of transcription factors whose forced expression can reprogram differentiated somatic cells into induced pluripotent stem cells.
-
A.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases
The Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases is a research consortium focused on understanding how cellular stress mechanisms contribute to aging and age-related diseases to develop new therapeutic strategies.
-
B.
Center for Cellular and Molecular Therapeutics
The Center for Cellular and Molecular Therapeutics is a research institute specializing in developing gene and cell-based therapies for pediatric and genetic diseases.
-
C.
Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
-
D.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
-
E.
The Cell
The Cell is a nickname for the Chicago White Sox’s home ballpark, officially known for much of its history as U.S. Cellular Field.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf | set of transcription factors ⓘ |
| alsoKnownAs |
OSKM factors
ⓘ
Yamanaka factors ⓘ reprogramming factors ⓘ |
| associatedWith |
embryonic stem cell–like gene expression program
ⓘ
induced pluripotent stem cells ⓘ |
| biologicalProcess |
cellular reprogramming
ⓘ
epigenetic reprogramming ⓘ induction of pluripotency ⓘ |
| cellTypeReprogrammed |
human fibroblasts
ⓘ
mouse fibroblasts ⓘ various somatic cell types ⓘ |
| componentRole |
Klf4 regulates proliferation and self-renewal
ⓘ
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc self-linksurface differs ⓘ
surface form:
Oct3/4 maintains pluripotency
Sox2 maintains pluripotency ⓘ c-Myc promotes proliferation and chromatin remodeling ⓘ |
| deliveryMethod |
Sendai virus vectors
ⓘ
episomal plasmids ⓘ lentiviral vectors ⓘ mRNA transfection ⓘ non-integrating vectors ⓘ protein transduction ⓘ retroviral vectors ⓘ |
| discoveredBy | Shinya Yamanaka ⓘ |
| discoveryYear | 2006 ⓘ |
| function | reprogram differentiated somatic cells into induced pluripotent stem cells ⓘ |
| hasMember |
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
self-linksurface differs
ⓘ
surface form:
Klf4
Oct3/4 ⓘ Sox2 ⓘ c-Myc ⓘ |
| induces | expression of pluripotency-associated genes ⓘ |
| molecularFunction | DNA-binding transcription factor activity ⓘ |
| organismContext |
Homo sapiens
ⓘ
house mouse (Mus musculus) ⓘ
surface form:
Mus musculus
|
| pathway | pluripotency network regulation ⓘ |
| relatedAward |
Nobel Prize in Physiology or Medicine
ⓘ
surface form:
Nobel Prize in Physiology or Medicine 2012
|
| relatedField |
cellular reprogramming research
ⓘ
regenerative medicine ⓘ stem cell biology ⓘ |
| risk |
genomic instability
ⓘ
tumorigenesis ⓘ |
| suppresses | differentiation-associated genes ⓘ |
| usedFor |
disease modeling
ⓘ
drug screening ⓘ generation of induced pluripotent stem cells ⓘ regenerative medicine research ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc Description of subject: Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc are a set of transcription factors whose forced expression can reprogram differentiated somatic cells into induced pluripotent stem cells.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
→
hasMember
→
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
self-linksurface differs
ⓘ
this entity surface form:
Klf4
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
→
componentRole
→
Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc
self-linksurface differs
ⓘ
this entity surface form:
Oct3/4 maintains pluripotency