Guillain–Barré syndrome

E196711

acute inflammatory demyelinating polyradiculoneuropathy autoimmune disease neurological disorder peripheral neuropathy

Guillain–Barré syndrome is an acute autoimmune disorder in which the immune system attacks peripheral nerves, leading to rapidly progressive muscle weakness and potential paralysis, often triggered by infections such as Campylobacter.

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All labels observed (5)

Label	Occurrences
Guillain–Barré syndrome canonical	5
Miller Fisher syndrome	1
acute inflammatory demyelinating polyradiculoneuropathy	1
acute motor and sensory axonal neuropathy	1
acute motor axonal neuropathy	1

Statements (66)

Predicate	Object
instanceOf	acute inflammatory demyelinating polyradiculoneuropathy ⓘ autoimmune disease ⓘ neurological disorder ⓘ peripheral neuropathy ⓘ
affectsSystem	peripheral nervous system ⓘ
canAffect	children ⓘ
hasCause	autoimmune attack on peripheral nerves ⓘ
hasClinicalCourse	acute ⓘ monophasic ⓘ
hasComplication	chronic neuropathic pain ⓘ deep vein thrombosis ⓘ paralysis ⓘ pulmonary embolism ⓘ respiratory failure ⓘ
hasDiagnosticFinding	albuminocytologic dissociation in cerebrospinal fluid ⓘ
hasDiagnosticTest	electromyography ⓘ lumbar puncture ⓘ nerve conduction studies ⓘ
hasIncidence	about 1 to 2 cases per 100000 person-years ⓘ
hasMortalityRate	approximately 3–7 percent ⓘ
hasOnsetPattern	rapidly progressive ⓘ
hasPathophysiology	immune-mediated axonal damage ⓘ immune-mediated demyelination of peripheral nerves ⓘ
hasPrimarySymptom	areflexia ⓘ ascending muscle weakness ⓘ hyporeflexia ⓘ
hasPrognosis	most patients recover partially or completely ⓘ
hasSexDistribution	slightly more common in males ⓘ
hasSubtype	Guillain–Barré syndrome self-linksurface differs ⓘ surface form: Miller Fisher syndrome Guillain–Barré syndrome self-linksurface differs ⓘ surface form: acute inflammatory demyelinating polyradiculoneuropathy Guillain–Barré syndrome self-linksurface differs ⓘ surface form: acute motor and sensory axonal neuropathy Guillain–Barré syndrome self-linksurface differs ⓘ surface form: acute motor axonal neuropathy
hasSymptom	autonomic dysfunction ⓘ blood pressure instability ⓘ bulbar weakness ⓘ cardiac arrhythmia ⓘ facial weakness ⓘ gait disturbance ⓘ numbness in extremities ⓘ paresthesia ⓘ respiratory muscle weakness ⓘ
hasSynonym	GBS ⓘ acute inflammatory demyelinating polyneuropathy ⓘ
hasTreatment	intravenous immunoglobulin ⓘ mechanical ventilation ⓘ physical rehabilitation ⓘ plasma exchange ⓘ supportive care ⓘ thromboprophylaxis ⓘ
hasTypicalAgeGroup	adults ⓘ
hasTypicalTrigger	Campylobacter jejuni infection ⓘ Epstein–Barr virus infection ⓘ Mycoplasma pneumoniae infection ⓘ Zika virus infection ⓘ cytomegalovirus infection ⓘ gastrointestinal infection ⓘ infection ⓘ influenza infection ⓘ respiratory tract infection ⓘ surgery ⓘ vaccination ⓘ
isClassifiedUnder	immune-mediated neuropathies ⓘ rare diseases ⓘ
wasFirstDescribedBy	Georges Guillain ⓘ Jean Alexandre Barré ⓘ
wasFirstDescribedInYear	1916 ⓘ

Referenced by (9)

Full triples — surface form annotated when it differs from this entity's canonical label.

Campylobacter → complication → Guillain–Barré syndrome ⓘ

Janssen COVID-19 Vaccine → rareAdverseEvents → Guillain–Barré syndrome ⓘ

2015–2016 Zika virus outbreak → associatedWith → Guillain–Barré syndrome ⓘ

Guillain–Barré syndrome → hasSubtype → Guillain–Barré syndrome self-linksurface differs ⓘ

this entity surface form: acute inflammatory demyelinating polyradiculoneuropathy

Guillain–Barré syndrome → hasSubtype → Guillain–Barré syndrome self-linksurface differs ⓘ

this entity surface form: acute motor axonal neuropathy

Guillain–Barré syndrome → hasSubtype → Guillain–Barré syndrome self-linksurface differs ⓘ

this entity surface form: acute motor and sensory axonal neuropathy

Guillain–Barré syndrome → hasSubtype → Guillain–Barré syndrome self-linksurface differs ⓘ

this entity surface form: Miller Fisher syndrome

Ad26.COV2.S → adverseEventOfSpecialInterest → Guillain–Barré syndrome ⓘ

Zika virus → associatedCondition → Guillain–Barré syndrome ⓘ