Epstein–Barr virus infection
E727688
Epstein–Barr virus infection is a common herpesvirus illness that can cause infectious mononucleosis and is associated with various autoimmune and neurological complications.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Epstein–Barr virus infection canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T8357219 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Epstein–Barr virus infection Context triple: [Guillain–Barré syndrome, hasTypicalTrigger, Epstein–Barr virus infection]
-
A.
EBV
EBV is the National Rail station code for Ebbw Vale Parkway railway station in Wales.
-
B.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
C.
Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
JC virus
JC virus is a human polyomavirus that typically causes asymptomatic infection but can lead to severe demyelinating brain disease in immunocompromised individuals.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Epstein–Barr virus infection Target entity description: Epstein–Barr virus infection is a common herpesvirus illness that can cause infectious mononucleosis and is associated with various autoimmune and neurological complications.
-
A.
EBV
EBV is the National Rail station code for Ebbw Vale Parkway railway station in Wales.
-
B.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
C.
Hodgkin lymphoma
Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, characterized by the presence of abnormal Reed–Sternberg cells and often affecting lymph nodes.
-
D.
Hodgkin
Hodgkin is a surname most famously associated with Dorothy Hodgkin, the Nobel Prize–winning British chemist who advanced the field of X-ray crystallography.
-
E.
JC virus
JC virus is a human polyomavirus that typically causes asymptomatic infection but can lead to severe demyelinating brain disease in immunocompromised individuals.
- F. None of above. chosen
Statements (72)
| Predicate | Object |
|---|---|
| instanceOf |
human disease
ⓘ
viral infectious disease ⓘ |
| antiviralTherapyRole | limited in uncomplicated infectious mononucleosis ⓘ |
| associatedWithDisease |
Bell palsy
ⓘ
Burkitt lymphoma NERFINISHED ⓘ Guillain–Barré syndrome NERFINISHED ⓘ Hodgkin lymphoma NERFINISHED ⓘ acute cerebellar ataxia ⓘ autoimmune hemolytic anemia ⓘ chronic active Epstein–Barr virus disease ⓘ encephalitis ⓘ gastric carcinoma ⓘ hemophagocytic lymphohistiocytosis ⓘ hepatitis ⓘ immune thrombocytopenic purpura ⓘ interstitial pneumonia ⓘ meningoencephalitis ⓘ multiple sclerosis ⓘ myocarditis ⓘ nasopharyngeal carcinoma ⓘ oral hairy leukoplakia ⓘ peripheral neuropathy ⓘ post-transplant lymphoproliferative disorder ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus ⓘ |
| causedBy | Epstein–Barr virus NERFINISHED ⓘ |
| commonSign |
hepatomegaly
ⓘ
splenomegaly ⓘ |
| commonSymptom |
fatigue
ⓘ
fever ⓘ lymphadenopathy ⓘ malaise ⓘ pharyngitis ⓘ sore throat ⓘ |
| complication |
airway obstruction due to tonsillar hypertrophy
ⓘ
chronic fatigue ⓘ splenic rupture ⓘ |
| course | often self-limited in immunocompetent hosts ⓘ |
| diagnosticTest |
EBV DNA PCR
NERFINISHED
ⓘ
EBV-specific serology ⓘ heterophile antibody test ⓘ |
| establishes | lifelong latency ⓘ |
| geographicDistribution | worldwide ⓘ |
| hasVirusFamily | Herpesviridae NERFINISHED ⓘ |
| hasVirusGenus | Lymphocryptovirus NERFINISHED ⓘ |
| hasVirusSpecies | Human gammaherpesvirus 4 ⓘ |
| hasVirusSubfamily | Gammaherpesvirinae NERFINISHED ⓘ |
| hematologicFinding |
atypical lymphocytosis
ⓘ
lymphocytosis ⓘ |
| higherRiskGroup |
HIV-infected individuals
ⓘ
immunocompromised patients ⓘ organ transplant recipients ⓘ |
| latencySite | memory B cells ⓘ |
| preventionStatus | no widely available licensed vaccine as of 2024 ⓘ |
| primaryTargetCells |
B lymphocytes
ⓘ
epithelial cells ⓘ |
| reactivationPossible | true ⓘ |
| serologicMarker |
EBNA antibodies
ⓘ
VCA IgG antibodies ⓘ VCA IgM antibodies ⓘ heterophile antibodies ⓘ |
| seroprevalence | infects majority of humans by adulthood ⓘ |
| transmissionRoute |
blood transfusion
ⓘ
oral contact ⓘ organ transplantation ⓘ saliva ⓘ |
| typicalAgePrimaryInfection | childhood ⓘ |
| typicalAgeSymptomaticMononucleosis |
adolescence
ⓘ
young adulthood ⓘ |
| typicalClinicalSyndrome |
glandular fever
ⓘ
infectious mononucleosis ⓘ |
| usualTreatment | supportive care ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Epstein–Barr virus infection Description of subject: Epstein–Barr virus infection is a common herpesvirus illness that can cause infectious mononucleosis and is associated with various autoimmune and neurological complications.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.