Epstein–Barr virus infection
E727688
Epstein–Barr virus infection is a common herpesvirus illness that can cause infectious mononucleosis and is associated with various autoimmune and neurological complications.
Statements (72)
| Predicate | Object |
|---|---|
| instanceOf |
human disease
ⓘ
viral infectious disease ⓘ |
| antiviralTherapyRole | limited in uncomplicated infectious mononucleosis ⓘ |
| associatedWithDisease |
Bell palsy
ⓘ
Burkitt lymphoma NERFINISHED ⓘ Guillain–Barré syndrome NERFINISHED ⓘ Hodgkin lymphoma NERFINISHED ⓘ acute cerebellar ataxia ⓘ autoimmune hemolytic anemia ⓘ chronic active Epstein–Barr virus disease ⓘ encephalitis ⓘ gastric carcinoma ⓘ hemophagocytic lymphohistiocytosis ⓘ hepatitis ⓘ immune thrombocytopenic purpura ⓘ interstitial pneumonia ⓘ meningoencephalitis ⓘ multiple sclerosis ⓘ myocarditis ⓘ nasopharyngeal carcinoma ⓘ oral hairy leukoplakia ⓘ peripheral neuropathy ⓘ post-transplant lymphoproliferative disorder ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus ⓘ |
| causedBy | Epstein–Barr virus NERFINISHED ⓘ |
| commonSign |
hepatomegaly
ⓘ
splenomegaly ⓘ |
| commonSymptom |
fatigue
ⓘ
fever ⓘ lymphadenopathy ⓘ malaise ⓘ pharyngitis ⓘ sore throat ⓘ |
| complication |
airway obstruction due to tonsillar hypertrophy
ⓘ
chronic fatigue ⓘ splenic rupture ⓘ |
| course | often self-limited in immunocompetent hosts ⓘ |
| diagnosticTest |
EBV DNA PCR
NERFINISHED
ⓘ
EBV-specific serology ⓘ heterophile antibody test ⓘ |
| establishes | lifelong latency ⓘ |
| geographicDistribution | worldwide ⓘ |
| hasVirusFamily | Herpesviridae NERFINISHED ⓘ |
| hasVirusGenus | Lymphocryptovirus NERFINISHED ⓘ |
| hasVirusSpecies | Human gammaherpesvirus 4 ⓘ |
| hasVirusSubfamily | Gammaherpesvirinae NERFINISHED ⓘ |
| hematologicFinding |
atypical lymphocytosis
ⓘ
lymphocytosis ⓘ |
| higherRiskGroup |
HIV-infected individuals
ⓘ
immunocompromised patients ⓘ organ transplant recipients ⓘ |
| latencySite | memory B cells ⓘ |
| preventionStatus | no widely available licensed vaccine as of 2024 ⓘ |
| primaryTargetCells |
B lymphocytes
ⓘ
epithelial cells ⓘ |
| reactivationPossible | true ⓘ |
| serologicMarker |
EBNA antibodies
ⓘ
VCA IgG antibodies ⓘ VCA IgM antibodies ⓘ heterophile antibodies ⓘ |
| seroprevalence | infects majority of humans by adulthood ⓘ |
| transmissionRoute |
blood transfusion
ⓘ
oral contact ⓘ organ transplantation ⓘ saliva ⓘ |
| typicalAgePrimaryInfection | childhood ⓘ |
| typicalAgeSymptomaticMononucleosis |
adolescence
ⓘ
young adulthood ⓘ |
| typicalClinicalSyndrome |
glandular fever
ⓘ
infectious mononucleosis ⓘ |
| usualTreatment | supportive care ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.