downregulatedBy

P149277
predicate

Indicates that the level, activity, or expression of one entity is decreased as a result of the influence or action of another entity.

All labels observed (3)

Label Occurrences
downregulatedBy canonical 5
negativelyRegulatedBy 3
canDecreaseSynthesisOf 2

Description generation (PDg)

The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.

Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning.  
# Instructions
Focus on describing the relationship, not the entities themselves. 
# Response Format
Begin the description with \' Indicates...\'
Input
Predicate: downregulatedBy
Generated description
Indicates that the level, activity, or expression of one entity is decreased as a result of the influence or action of another entity.

Sample triples (10)

Subject Object
IL-17A IL-27
IL-17A IFN-γ
IL-17A IL-4
tumor necrosis factor alpha glucocorticoid
tumor necrosis factor alpha IL-10 NERFINISHED
ketoconazole cortisol via predicate surface "canDecreaseSynthesisOf"
ketoconazole testosterone via predicate surface "canDecreaseSynthesisOf"
MAPK signaling pathway MAPK phosphatases via predicate surface "negativelyRegulatedBy" NERFINISHED
MAPK signaling pathway protein phosphatase 2A via predicate surface "negativelyRegulatedBy"
MAPK signaling pathway Sprouty proteins via predicate surface "negativelyRegulatedBy" NERFINISHED