IL-17A
E561033
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
Statements (56)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
interleukin ⓘ pro-inflammatory cytokine ⓘ protein ⓘ |
| activatesPathway |
C/EBP signaling pathway
ⓘ
MAPK signaling pathway NERFINISHED ⓘ NF-κB signaling pathway ⓘ |
| alternativeName |
CTLA-8
NERFINISHED
ⓘ
interleukin-17A ⓘ |
| associatedWithDisease |
Crohn's disease
ⓘ
ankylosing spondylitis ⓘ asthma ⓘ autoimmune disease ⓘ chronic inflammatory disease ⓘ inflammatory bowel disease ⓘ multiple sclerosis NERFINISHED ⓘ psoriasis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus ⓘ ulcerative colitis ⓘ |
| belongsToFamily | IL-17 cytokine family NERFINISHED ⓘ |
| bindsTo | IL-17 receptor complex NERFINISHED ⓘ |
| chromosomalLocationOfGene | human chromosome 6p12 ⓘ |
| downregulatedBy |
IFN-γ
ⓘ
IL-27 ⓘ IL-4 ⓘ |
| encodedBy | IL17A gene NERFINISHED ⓘ |
| expressedByTissue |
inflamed synovium
ⓘ
psoriatic skin lesion ⓘ |
| formsHeterodimer | IL-17A/F heterodimer ⓘ |
| formsHomodimer | IL-17A homodimer ⓘ |
| formsReceptorComplexWith | IL-17RA–IL-17RC heterodimer ⓘ |
| induces |
G-CSF production
ⓘ
antimicrobial peptide production ⓘ chemokine production ⓘ neutrophil recruitment ⓘ pro-inflammatory cytokine production ⓘ |
| producedByCellType |
CD4-positive T cell
ⓘ
CD8-positive T cell NERFINISHED ⓘ NK cell ⓘ Th17 cell ⓘ innate lymphoid cell ⓘ mast cell ⓘ neutrophil ⓘ γδ T cell ⓘ |
| receptor |
IL-17RA
NERFINISHED
ⓘ
IL-17RC ⓘ |
| roleInProcess |
host defense against extracellular bacteria
ⓘ
host defense against fungi ⓘ |
| secretedBy | activated Th17 cell ⓘ |
| therapeuticTargetOf |
ixekizumab
NERFINISHED
ⓘ
netakimab NERFINISHED ⓘ secukinumab NERFINISHED ⓘ |
| upregulatedBy |
IL-23
ⓘ
TGF-β plus IL-6 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.