MAPK signaling pathway
E902874
The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
intracellular signaling cascade
ⓘ
signal transduction pathway ⓘ |
| activatedBy |
G protein–coupled receptors
NERFINISHED
ⓘ
cytokine receptors ⓘ growth factors ⓘ integrins ⓘ mitogens ⓘ receptor tyrosine kinases ⓘ stress stimuli ⓘ |
| associatedWith |
cancer
ⓘ
cardiovascular diseases ⓘ inflammatory diseases ⓘ neurodegenerative diseases ⓘ |
| conservedIn |
eukaryotes
ⓘ
mammals ⓘ yeast ⓘ |
| hasComponent |
ERK kinase
NERFINISHED
ⓘ
JNK kinase NERFINISHED ⓘ MAPK phosphatases ⓘ MEK kinase NERFINISHED ⓘ Raf kinase NERFINISHED ⓘ Ras protein NERFINISHED ⓘ p38 MAPK NERFINISHED ⓘ scaffold proteins ⓘ |
| hasSubPathway |
ERK1/2 pathway
ⓘ
ERK5 pathway NERFINISHED ⓘ JNK pathway ⓘ p38 MAPK pathway NERFINISHED ⓘ |
| negativelyRegulatedBy |
MAPK phosphatases
NERFINISHED
ⓘ
Sprouty proteins NERFINISHED ⓘ protein phosphatase 2A ⓘ |
| occursIn |
cell nucleus
ⓘ
cytoplasm ⓘ plasma membrane ⓘ |
| phosphorylates |
cytoskeletal proteins
ⓘ
other kinases ⓘ transcription factors ⓘ |
| regulates |
apoptosis
ⓘ
cell cycle progression ⓘ cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ developmental processes ⓘ differentiation of immune cells ⓘ gene expression ⓘ inflammatory responses ⓘ neuronal plasticity ⓘ stress responses ⓘ |
| targetOf | small molecule kinase inhibitors ⓘ |
| transmitsSignalFrom | cell surface receptors ⓘ |
| transmitsSignalTo | nuclear transcription factors ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.