CYP3A5

E905090
cytochrome P450 enzyme drug-metabolizing enzyme enzyme protein

CYP3A5 is a liver-expressed cytochrome P450 enzyme that metabolizes various drugs and xenobiotics, contributing to interindividual variability in drug clearance.

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Statements (56)

Predicate Object
instanceOf cytochrome P450 enzyme ⓘ
drug-metabolizing enzyme ⓘ
enzyme ⓘ
protein ⓘ
affects calcineurin inhibitor pharmacokinetics ⓘ
tacrolimus dose requirements ⓘ
alleleCYP3A5*1 expressor allele ⓘ
alleleCYP3A5*3 non-expressor allele ⓘ
alleleCYP3A5*6 non-functional allele ⓘ
alleleCYP3A5*7 non-functional allele ⓘ
contributesTo first-pass metabolism of orally administered drugs ⓘ
interindividual variability in drug clearance ⓘ
encodedBy CYP3A5 gene NERFINISHED ⓘ
foundInTaxon Homo sapiens NERFINISHED ⓘ
hasAllele CYP3A5*1 ⓘ
CYP3A5*3 NERFINISHED ⓘ
CYP3A5*6 NERFINISHED ⓘ
CYP3A5*7 NERFINISHED ⓘ
hasBiologicalProcess drug metabolic process ⓘ
oxidation-reduction process ⓘ
steroid metabolic process ⓘ
xenobiotic metabolic process ⓘ
hasCofactor heme ⓘ
hasMolecularFunction drug binding ⓘ
monooxygenase activity ⓘ
oxidoreductase activity ⓘ
highlyExpressedIn CYP3A5*1 carriers ⓘ
inducedBy carbamazepine NERFINISHED ⓘ
rifampin NERFINISHED ⓘ
inhibitedBy azole antifungals ⓘ
macrolide antibiotics ⓘ
isClinicallyRelevantFor pharmacogenomics ⓘ
isPolymorphic true ⓘ
locatedIn adrenal gland ⓘ
endoplasmic reticulum membrane ⓘ
intestine ⓘ
kidney ⓘ
liver ⓘ
lowOrAbsentExpressionIn CYP3A5*3 homozygotes ⓘ
memberOf CYP3A subfamily NERFINISHED ⓘ
cytochrome P450 superfamily NERFINISHED ⓘ
metabolizes carbamazepine ⓘ
cyclosporine ⓘ
endogenous steroids ⓘ
midazolam NERFINISHED ⓘ
nifedipine NERFINISHED ⓘ
protease inhibitors ⓘ
statins ⓘ
tacrolimus ⓘ
orthologInHuman CYP3A5 NERFINISHED ⓘ
regulatedBy constitutive androstane receptor NERFINISHED ⓘ
pregnane X receptor NERFINISHED ⓘ
requires NADPH ⓘ
cytochrome P450 reductase NERFINISHED ⓘ
subcellularLocation microsome ⓘ
usesSubstrate lipophilic compounds ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

docetaxel → primaryMetabolismEnzyme → CYP3A5 ⓘ
subject surface form: Docetaxel