clarithromycin
E850012
CYP3A4 inhibitor
CYP3A5 inhibitor
CYP3A7 inhibitor
antibacterial drug
macrolide antibiotic
prokinetic agent
Clarithromycin is a macrolide antibiotic commonly used to treat respiratory and other bacterial infections and known for significant drug–drug interactions due to its inhibition of CYP3A4.
All labels observed (1)
| Label | Occurrences |
|---|---|
| clarithromycin canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214778 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: clarithromycin Context triple: [CYP3A4, inhibitedBy, clarithromycin]
-
A.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
B.
Kotramide
Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
-
C.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
D.
Doxato
Doxato is a town in northern Greece located within the Drama regional unit, known for its agricultural surroundings and historical significance.
-
E.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: clarithromycin Target entity description: Clarithromycin is a macrolide antibiotic commonly used to treat respiratory and other bacterial infections and known for significant drug–drug interactions due to its inhibition of CYP3A4.
-
A.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
B.
Kotramide
Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
-
C.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
D.
Doxato
Doxato is a town in northern Greece located within the Drama regional unit, known for its agricultural surroundings and historical significance.
-
E.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
- F. None of above. chosen
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
CYP3A4 inhibitor
ⓘ
CYP3A5 inhibitor ⓘ CYP3A7 inhibitor ⓘ antibacterial drug ⓘ macrolide antibiotic ⓘ prokinetic agent ⓘ |
| developedFrom | erythromycin ⓘ |
| hasActiveMetabolite | 14-hydroxyclarithromycin ⓘ |
| hasAntibacterialSpectrum |
Gram-positive bacteria
ⓘ
atypical respiratory pathogens ⓘ some Gram-negative bacteria ⓘ |
| hasATCCode | J01FA09 ⓘ |
| hasBioavailability | about 50% ⓘ |
| hasBrandName |
Biaxin
NERFINISHED
ⓘ
Klacid NERFINISHED ⓘ Klaricid NERFINISHED ⓘ |
| hasCASNumber | 81103-11-9 ⓘ |
| hasChemicalFormula | C38H69NO13 ⓘ |
| hasCommonAdverseEffect |
abdominal pain
ⓘ
diarrhea ⓘ dysgeusia ⓘ gastrointestinal upset ⓘ nausea ⓘ |
| hasContraindication |
concomitant use with certain CYP3A4 substrates that prolong QT interval
ⓘ
history of cholestatic jaundice or hepatic dysfunction associated with prior clarithromycin use ⓘ |
| hasDosageForm |
extended-release tablet
ⓘ
oral suspension ⓘ tablet ⓘ |
| hasDrugBankID | DB01211 ⓘ |
| hasDrugInteractionType | increases plasma concentrations of CYP3A4 substrates ⓘ |
| hasEliminationHalfLife | 3 to 7 hours ⓘ |
| hasFunctionalGroup |
dimethylamino sugar
ⓘ
macrolide lactone ring ⓘ |
| hasIUPACName | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-(methoxyimino)-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione ⓘ |
| hasMechanismOfAction | inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit ⓘ |
| hasMolarMass | 747.95 g/mol ⓘ |
| hasProteinBinding | about 70% ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasSeriousAdverseEffect |
QT interval prolongation
ⓘ
hepatotoxicity ⓘ torsades de pointes ⓘ |
| hasTarget | bacterial 50S ribosomal subunit ⓘ |
| hasUNII | K8OR5YW8X6 ⓘ |
| inhibits |
CYP3A4
NERFINISHED
ⓘ
P-glycoprotein NERFINISHED ⓘ |
| isExcretedVia |
feces
ⓘ
urine ⓘ |
| isMetabolizedBy | CYP3A4 NERFINISHED ⓘ |
| isOn | World Health Organization Model List of Essential Medicines NERFINISHED ⓘ |
| isPregnancyCategory | Category C (US, historical) ⓘ |
| isSemisyntheticDerivativeOf | erythromycin A NERFINISHED ⓘ |
| isUsedFor |
Helicobacter pylori eradication
ⓘ
Mycobacterium avium complex infections ⓘ acute bacterial exacerbation of chronic bronchitis ⓘ acute maxillary sinusitis ⓘ community-acquired pneumonia ⓘ otitis media ⓘ pharyngitis ⓘ skin and soft tissue infections ⓘ tonsillitis ⓘ |
| wasApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: clarithromycin Description of subject: Clarithromycin is a macrolide antibiotic commonly used to treat respiratory and other bacterial infections and known for significant drug–drug interactions due to its inhibition of CYP3A4.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.