Dobzhansky–Muller incompatibilities
E725886
Dobzhansky–Muller incompatibilities are genetic conflicts between interacting genes that evolve in separate populations, causing reduced fitness or sterility in their hybrids and thereby contributing to reproductive isolation and speciation.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Dobzhansky–Muller incompatibilities canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T8321136 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Dobzhansky–Muller incompatibilities Context triple: [Haldane’s rule, relatedConcept, Dobzhansky–Muller incompatibilities]
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A.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
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B.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
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C.
Genetics and the Origin of Species
Genetics and the Origin of Species is a 1937 book by Theodosius Dobzhansky that helped found the modern evolutionary synthesis by integrating Mendelian genetics with Darwinian natural selection.
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D.
Evolution and the Genetics of Populations
Evolution and the Genetics of Populations is a foundational multi-volume work in population genetics that systematically presents Sewall Wright’s theories on genetic drift, inbreeding, selection, and the evolutionary process.
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E.
Haldane’s dilemma
Haldane’s dilemma is a theoretical argument in population genetics that questions how rapidly beneficial genetic substitutions can accumulate in a population given the reproductive cost of natural selection.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Dobzhansky–Muller incompatibilities Target entity description: Dobzhansky–Muller incompatibilities are genetic conflicts between interacting genes that evolve in separate populations, causing reduced fitness or sterility in their hybrids and thereby contributing to reproductive isolation and speciation.
-
A.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
-
B.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
-
C.
Genetics and the Origin of Species
Genetics and the Origin of Species is a 1937 book by Theodosius Dobzhansky that helped found the modern evolutionary synthesis by integrating Mendelian genetics with Darwinian natural selection.
-
D.
Evolution and the Genetics of Populations
Evolution and the Genetics of Populations is a foundational multi-volume work in population genetics that systematically presents Sewall Wright’s theories on genetic drift, inbreeding, selection, and the evolutionary process.
-
E.
Haldane’s dilemma
Haldane’s dilemma is a theoretical argument in population genetics that questions how rapidly beneficial genetic substitutions can accumulate in a population given the reproductive cost of natural selection.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
genetic incompatibility model
ⓘ
reproductive isolation mechanism ⓘ speciation mechanism ⓘ |
| appliesTo |
mitochondrial–nuclear interactions
ⓘ
nuclear genes ⓘ sex chromosome–autosome interactions ⓘ |
| assumes | allopatric divergence of populations ⓘ |
| basedOn |
epistasis
ⓘ
fixation of different alleles in isolated populations ⓘ |
| contrastsWith | single-locus underdominance models of isolation ⓘ |
| contributesTo |
genetic barriers to gene flow
ⓘ
speciation ⓘ |
| describes |
genetic conflicts between interacting loci fixed in different populations
ⓘ
hybrid inviability ⓘ hybrid sterility ⓘ postzygotic reproductive isolation ⓘ |
| emergesWhen | hybrid combines incompatible derived alleles ⓘ |
| explains |
evolution of intrinsic postzygotic isolation
ⓘ
how hybrid problems can evolve without reduced fitness in parental populations ⓘ |
| field |
evolutionary biology
ⓘ
population genetics ⓘ speciation genetics ⓘ |
| hasCause | epistatic interactions between derived alleles from different populations ⓘ |
| hasComponent |
derived allele in population 1
ⓘ
derived allele in population 2 ⓘ |
| hasEffect |
hybrid inviability
ⓘ
hybrid sterility ⓘ postzygotic reproductive isolation between populations ⓘ reduced hybrid fitness ⓘ |
| interactionType | negative epistasis ⓘ |
| namedAfter |
Hermann Joseph Muller
NERFINISHED
ⓘ
Theodosius Dobzhansky NERFINISHED ⓘ |
| predicts |
incompatibilities can accumulate faster than linearly with divergence
ⓘ
multiple loci contribute to reproductive isolation ⓘ |
| relatedConcept | Bateson–Dobzhansky–Muller model NERFINISHED ⓘ |
| relatedTo |
Haldane's rule
NERFINISHED
ⓘ
genetic architecture of speciation ⓘ |
| supports | biological species concept ⓘ |
| testedIn |
Drosophila
NERFINISHED
ⓘ
mammals ⓘ plants ⓘ yeast ⓘ |
| timeScale | can accumulate gradually over evolutionary time ⓘ |
| usedIn |
genome scan studies of reproductive barriers
ⓘ
quantitative genetic studies of hybrid fitness ⓘ theoretical models of speciation ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Dobzhansky–Muller incompatibilities Description of subject: Dobzhansky–Muller incompatibilities are genetic conflicts between interacting genes that evolve in separate populations, causing reduced fitness or sterility in their hybrids and thereby contributing to reproductive isolation and speciation.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.