voriconazole
E556657
Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
azole antifungal
ⓘ
broad-spectrum antifungal agent ⓘ triazole antifungal drug ⓘ |
| affectsPathway | ergosterol biosynthesis ⓘ |
| hasAdministrationForm |
intravenous solution
ⓘ
oral suspension ⓘ tablet ⓘ |
| hasATCCode | J02AC03 ⓘ |
| hasBrandName | Vfend NERFINISHED ⓘ |
| hasChemicalClass | triazole ⓘ |
| hasCommonAdverseEffect |
elevated liver enzymes
ⓘ
photosensitivity ⓘ rash ⓘ visual disturbances ⓘ |
| hasContraindication | coadministration with certain CYP3A4 substrates that prolong QT interval ⓘ |
| hasDrugInteraction |
CYP3A4 inducers
ⓘ
CYP3A4 inhibitors ⓘ carbamazepine ⓘ phenytoin NERFINISHED ⓘ rifampin ⓘ |
| hasEffect | disruption of fungal cell membrane formation ⓘ |
| hasMechanismOfAction | inhibition of fungal cytochrome P450–dependent 14α-sterol demethylase ⓘ |
| hasPharmacokineticsProperty |
high oral bioavailability
ⓘ
nonlinear pharmacokinetics ⓘ |
| hasPregnancyCategory | D (US, historical classification) ⓘ |
| hasRouteConsideration | loading dose recommended for intravenous use ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasSeriousAdverseEffect |
QT interval prolongation
ⓘ
hepatotoxicity ⓘ torsades de pointes ⓘ |
| hasSpectrumOfActivity |
molds
ⓘ
yeasts ⓘ |
| hasTargetOrganism |
Aspergillus species
NERFINISHED
ⓘ
Candida species NERFINISHED ⓘ |
| inhibits | lanosterol 14α-demethylase ⓘ |
| isDerivedFrom | fluconazole analogue ⓘ |
| isIndicatedFor | immunocompromised patients with invasive fungal infections ⓘ |
| isMetabolizedBy |
CYP2C19
NERFINISHED
ⓘ
CYP2C9 NERFINISHED ⓘ CYP3A4 NERFINISHED ⓘ |
| treats |
Fusarium infections
ⓘ
Scedosporium infections ⓘ candidemia ⓘ esophageal candidiasis ⓘ invasive aspergillosis ⓘ invasive fungal infections ⓘ |
| wasApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.