EPAS1
E925672
EPAS1 is a human gene encoding a hypoxia-inducible transcription factor that plays a key role in adaptation to low-oxygen environments, notably implicated in high-altitude tolerance.
All labels observed (1)
| Label | Occurrences |
|---|---|
| EPAS1 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11456962 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: EPAS1 Context triple: [Denisovans, associatedGene, EPAS1]
-
A.
EPAS
EPAS is an international accreditation system for business and management programmes, recognized for assessing the quality and rigor of higher education offerings worldwide.
-
B.
EPAS
EPAS is the European Union’s strategic and regulatory framework for improving aviation safety across member states.
-
C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
D.
HDY
HDY is the IATA airport code for Hat Yai International Airport in southern Thailand, a key regional hub serving the city of Hat Yai and the surrounding area.
-
E.
HDY
HDY is the National Rail station code for Headingley railway station in Leeds, West Yorkshire, England.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: EPAS1 Target entity description: EPAS1 is a human gene encoding a hypoxia-inducible transcription factor that plays a key role in adaptation to low-oxygen environments, notably implicated in high-altitude tolerance.
-
A.
EPAS
EPAS is an international accreditation system for business and management programmes, recognized for assessing the quality and rigor of higher education offerings worldwide.
-
B.
EPAS
EPAS is the European Union’s strategic and regulatory framework for improving aviation safety across member states.
-
C.
GNAS
GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
-
D.
HDY
HDY is the IATA airport code for Hat Yai International Airport in southern Thailand, a key regional hub serving the city of Hat Yai and the surrounding area.
-
E.
HDY
HDY is the National Rail station code for Headingley railway station in Leeds, West Yorkshire, England.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ |
| associatedWithDisease |
familial erythrocytosis
ⓘ
neuroendocrine tumors ⓘ paraganglioma ⓘ pheochromocytoma ⓘ pulmonary hypertension ⓘ |
| associatedWithPopulation |
Andean high-altitude populations
NERFINISHED
ⓘ
Tibetan high-altitude populations ⓘ |
| associatedWithTrait |
hemoglobin concentration regulation
ⓘ
high-altitude adaptation ⓘ |
| bindsWith | ARNT NERFINISHED ⓘ |
| biologicalProcess |
adaptation to hypoxia
ⓘ
regulation of erythropoietin production ⓘ regulation of gene expression in response to oxygen levels ⓘ regulation of vascular development ⓘ |
| cellularComponent |
cytoplasm
ⓘ
nucleus ⓘ |
| containsDomain |
PAS domain
ⓘ
basic helix-loop-helix domain ⓘ oxygen-dependent degradation domain ⓘ |
| degradedUnderCondition | normoxia ⓘ |
| encodes |
endothelial PAS domain-containing protein 1
ⓘ
hypoxia-inducible transcription factor ⓘ |
| expressedIn |
endothelial cells
ⓘ
heart tissue ⓘ kidney tissue ⓘ lung tissue ⓘ |
| formsComplexWith | HIF-2 transcription factor complex NERFINISHED ⓘ |
| hasAlternativeName |
HIF-2α
NERFINISHED
ⓘ
HIF2A NERFINISHED ⓘ endothelial PAS domain protein 1 NERFINISHED ⓘ |
| hasGeneSymbol | EPAS1 ⓘ |
| locatedOnChromosome | human chromosome 2 ⓘ |
| locatedOnChromosomeArm | 2p ⓘ |
| molecularFunction |
DNA-binding transcription factor activity
ⓘ
hypoxia-inducible factor activity ⓘ protein heterodimerization activity ⓘ |
| organism | Homo sapiens ⓘ |
| participatesIn |
angiogenesis
ⓘ
cellular response to hypoxia ⓘ erythropoiesis regulation ⓘ transcriptional response to low oxygen levels ⓘ |
| pathway |
HIF signaling pathway
ⓘ
VEGF signaling pathway ⓘ erythropoietin signaling regulation ⓘ |
| regulatedBy |
prolyl hydroxylase domain proteins
ⓘ
von Hippel–Lindau protein NERFINISHED ⓘ |
| stabilizedUnderCondition | hypoxia ⓘ |
| undergoes | positive selection in some high-altitude human populations ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: EPAS1 Description of subject: EPAS1 is a human gene encoding a hypoxia-inducible transcription factor that plays a key role in adaptation to low-oxygen environments, notably implicated in high-altitude tolerance.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.