epidermal growth factor receptor family
E903677
The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.
All labels observed (3)
| Label | Occurrences |
|---|---|
| EGFR family | 1 |
| ERBB receptor family | 1 |
| epidermal growth factor receptor family canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074231 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: epidermal growth factor receptor family Context triple: [HER2 receptor, memberOf, epidermal growth factor receptor family]
-
A.
EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
-
B.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
C.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
D.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
E.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: epidermal growth factor receptor family Target entity description: The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.
-
A.
EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
-
B.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
C.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
-
D.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
E.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
- F. None of above. chosen
Statements (55)
| Predicate | Object |
|---|---|
| instanceOf |
growth factor receptor family
ⓘ
protein family ⓘ receptor tyrosine kinase family ⓘ |
| activatedBy |
epidermal growth factor
ⓘ
neuregulins ⓘ other EGF-like ligands ⓘ transforming growth factor alpha NERFINISHED ⓘ |
| activationMechanism | ligand-induced dimerization ⓘ |
| alternativeName |
ERBB family
NERFINISHED
ⓘ
HER receptor family NERFINISHED ⓘ |
| associatedWithDisease |
breast cancer
ⓘ
cancer ⓘ colorectal cancer ⓘ gastric cancer ⓘ glioblastoma ⓘ head and neck squamous cell carcinoma ⓘ non-small cell lung cancer ⓘ ovarian cancer ⓘ |
| downstreamPathway |
JAK-STAT pathway
ⓘ
PI3K-AKT pathway ⓘ PLCγ-PKC pathway ⓘ RAS-RAF-MEK-ERK pathway ⓘ |
| encodesProteinType | receptor tyrosine kinase ⓘ |
| evolutionarilyRelatedTo | vertebrate receptor tyrosine kinases ⓘ |
| formsComplexWith |
heterodimers
ⓘ
homodimers ⓘ |
| hasClinicalRelevance |
predictive biomarker for targeted therapy
ⓘ
prognostic biomarker in oncology ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasMember |
EGFR
NERFINISHED
ⓘ
ERBB1 NERFINISHED ⓘ ERBB2 NERFINISHED ⓘ ERBB3 NERFINISHED ⓘ ERBB4 NERFINISHED ⓘ HER1 NERFINISHED ⓘ HER2 NERFINISHED ⓘ HER3 ⓘ HER4 NERFINISHED ⓘ |
| isTargetOf |
antibody-drug conjugates
ⓘ
monoclonal antibodies ⓘ small-molecule inhibitors ⓘ tyrosine kinase inhibitors ⓘ |
| locatedIn | plasma membrane ⓘ |
| molecularAbnormality |
activating mutation
ⓘ
gene amplification ⓘ overexpression ⓘ |
| participatesIn |
cell differentiation regulation
ⓘ
cell migration regulation ⓘ cell proliferation regulation ⓘ cell survival regulation ⓘ developmental processes ⓘ signal transduction ⓘ |
| taxonomicScope | metazoans ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: epidermal growth factor receptor family Description of subject: The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.