epidermal growth factor receptor family
E903677
The epidermal growth factor receptor family is a group of closely related receptor tyrosine kinases (including EGFR/HER1, HER2, HER3, and HER4) that regulate cell growth, survival, and differentiation and are key targets in cancer biology and therapy.
Observed surface forms (2)
| Surface form | Occurrences |
|---|---|
| EGFR family | 1 |
| ERBB receptor family | 1 |
Statements (55)
| Predicate | Object |
|---|---|
| instanceOf |
growth factor receptor family
ⓘ
protein family ⓘ receptor tyrosine kinase family ⓘ |
| activatedBy |
epidermal growth factor
ⓘ
neuregulins ⓘ other EGF-like ligands ⓘ transforming growth factor alpha NERFINISHED ⓘ |
| activationMechanism | ligand-induced dimerization ⓘ |
| alternativeName |
ERBB family
NERFINISHED
ⓘ
HER receptor family NERFINISHED ⓘ |
| associatedWithDisease |
breast cancer
ⓘ
cancer ⓘ colorectal cancer ⓘ gastric cancer ⓘ glioblastoma ⓘ head and neck squamous cell carcinoma ⓘ non-small cell lung cancer ⓘ ovarian cancer ⓘ |
| downstreamPathway |
JAK-STAT pathway
ⓘ
PI3K-AKT pathway ⓘ PLCγ-PKC pathway ⓘ RAS-RAF-MEK-ERK pathway ⓘ |
| encodesProteinType | receptor tyrosine kinase ⓘ |
| evolutionarilyRelatedTo | vertebrate receptor tyrosine kinases ⓘ |
| formsComplexWith |
heterodimers
ⓘ
homodimers ⓘ |
| hasClinicalRelevance |
predictive biomarker for targeted therapy
ⓘ
prognostic biomarker in oncology ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasMember |
EGFR
NERFINISHED
ⓘ
ERBB1 NERFINISHED ⓘ ERBB2 NERFINISHED ⓘ ERBB3 NERFINISHED ⓘ ERBB4 NERFINISHED ⓘ HER1 NERFINISHED ⓘ HER2 NERFINISHED ⓘ HER3 ⓘ HER4 NERFINISHED ⓘ |
| isTargetOf |
antibody-drug conjugates
ⓘ
monoclonal antibodies ⓘ small-molecule inhibitors ⓘ tyrosine kinase inhibitors ⓘ |
| locatedIn | plasma membrane ⓘ |
| molecularAbnormality |
activating mutation
ⓘ
gene amplification ⓘ overexpression ⓘ |
| participatesIn |
cell differentiation regulation
ⓘ
cell migration regulation ⓘ cell proliferation regulation ⓘ cell survival regulation ⓘ developmental processes ⓘ signal transduction ⓘ |
| taxonomicScope | metazoans ⓘ |
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.