CYP2B6
E902894
CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CYP2B6 canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074513 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP2B6 Context triple: [cyclophosphamide, isMetabolizedBy, CYP2B6]
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
-
E.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP2B6 Target entity description: CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
-
E.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
- F. None of above. chosen
Statements (74)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ enzyme ⓘ protein ⓘ |
| associatedWith |
altered methadone maintenance dose requirements
ⓘ
efavirenz-induced central nervous system toxicity ⓘ interindividual variability in drug response ⓘ |
| cellularComponent |
integral component of membrane
ⓘ
microsome ⓘ |
| cofactor | heme ⓘ |
| encodedBy | CYP2B6 gene NERFINISHED ⓘ |
| expressedIn |
brain
ⓘ
intestine ⓘ kidney ⓘ liver ⓘ lung ⓘ |
| foundInTaxon | Homo sapiens NERFINISHED ⓘ |
| geneticVariationAffects |
bupropion clearance
ⓘ
cyclophosphamide activation ⓘ efavirenz plasma concentration ⓘ |
| hasECNumber | 1.14.14.1 ⓘ |
| hasMolecularWeight | approximately 56 kDa ⓘ |
| inducedBy |
St John’s wort
ⓘ
carbamazepine NERFINISHED ⓘ phenobarbital ⓘ phenytoin NERFINISHED ⓘ rifampicin NERFINISHED ⓘ |
| inhibitedBy |
clopidogrel
NERFINISHED
ⓘ
clotrimazole NERFINISHED ⓘ ketoconazole NERFINISHED ⓘ paroxetine NERFINISHED ⓘ sertraline NERFINISHED ⓘ thioTEPA NERFINISHED ⓘ ticlopidine NERFINISHED ⓘ |
| involvedIn |
N-demethylation of bupropion
ⓘ
N-demethylation of methadone ⓘ bioactivation of cyclophosphamide ⓘ bioactivation of ifosfamide ⓘ hydroxylation of efavirenz ⓘ hydroxylation of ketamine ⓘ |
| locatedIn | endoplasmic reticulum ⓘ |
| memberOf |
CYP2 family
NERFINISHED
ⓘ
CYP2B subfamily NERFINISHED ⓘ cytochrome P450 superfamily NERFINISHED ⓘ |
| molecularFunction |
drug binding
ⓘ
heme binding ⓘ iron ion binding ⓘ monooxygenase activity ⓘ oxidoreductase activity ⓘ |
| participatesIn |
drug metabolic process
ⓘ
fatty acid metabolic process ⓘ oxidation-reduction process ⓘ steroid metabolic process ⓘ xenobiotic metabolic process ⓘ |
| polymorphismIn |
CYP2B6*4 allele
ⓘ
CYP2B6*5 allele ⓘ CYP2B6*6 allele ⓘ CYP2B6*9 allele NERFINISHED ⓘ |
| regulatedBy |
constitutive androstane receptor
NERFINISHED
ⓘ
pregnane X receptor NERFINISHED ⓘ |
| substrateOf |
artemisinin
NERFINISHED
ⓘ
bupropion NERFINISHED ⓘ clopidogrel NERFINISHED ⓘ cyclophosphamide NERFINISHED ⓘ diazepam ⓘ efavirenz NERFINISHED ⓘ ifosfamide NERFINISHED ⓘ ketamine NERFINISHED ⓘ methadone NERFINISHED ⓘ nevirapine NERFINISHED ⓘ propofol ⓘ sertraline NERFINISHED ⓘ tamoxifen NERFINISHED ⓘ thiotepa ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP2B6 Description of subject: CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Velpatasvir