CYP2B6
E902894
CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
Statements (74)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ enzyme ⓘ protein ⓘ |
| associatedWith |
altered methadone maintenance dose requirements
ⓘ
efavirenz-induced central nervous system toxicity ⓘ interindividual variability in drug response ⓘ |
| cellularComponent |
integral component of membrane
ⓘ
microsome ⓘ |
| cofactor | heme ⓘ |
| encodedBy | CYP2B6 gene NERFINISHED ⓘ |
| expressedIn |
brain
ⓘ
intestine ⓘ kidney ⓘ liver ⓘ lung ⓘ |
| foundInTaxon | Homo sapiens NERFINISHED ⓘ |
| geneticVariationAffects |
bupropion clearance
ⓘ
cyclophosphamide activation ⓘ efavirenz plasma concentration ⓘ |
| hasECNumber | 1.14.14.1 ⓘ |
| hasMolecularWeight | approximately 56 kDa ⓘ |
| inducedBy |
St John’s wort
ⓘ
carbamazepine NERFINISHED ⓘ phenobarbital ⓘ phenytoin NERFINISHED ⓘ rifampicin NERFINISHED ⓘ |
| inhibitedBy |
clopidogrel
NERFINISHED
ⓘ
clotrimazole NERFINISHED ⓘ ketoconazole NERFINISHED ⓘ paroxetine NERFINISHED ⓘ sertraline NERFINISHED ⓘ thioTEPA NERFINISHED ⓘ ticlopidine NERFINISHED ⓘ |
| involvedIn |
N-demethylation of bupropion
ⓘ
N-demethylation of methadone ⓘ bioactivation of cyclophosphamide ⓘ bioactivation of ifosfamide ⓘ hydroxylation of efavirenz ⓘ hydroxylation of ketamine ⓘ |
| locatedIn | endoplasmic reticulum ⓘ |
| memberOf |
CYP2 family
NERFINISHED
ⓘ
CYP2B subfamily NERFINISHED ⓘ cytochrome P450 superfamily NERFINISHED ⓘ |
| molecularFunction |
drug binding
ⓘ
heme binding ⓘ iron ion binding ⓘ monooxygenase activity ⓘ oxidoreductase activity ⓘ |
| participatesIn |
drug metabolic process
ⓘ
fatty acid metabolic process ⓘ oxidation-reduction process ⓘ steroid metabolic process ⓘ xenobiotic metabolic process ⓘ |
| polymorphismIn |
CYP2B6*4 allele
ⓘ
CYP2B6*5 allele ⓘ CYP2B6*6 allele ⓘ CYP2B6*9 allele NERFINISHED ⓘ |
| regulatedBy |
constitutive androstane receptor
NERFINISHED
ⓘ
pregnane X receptor NERFINISHED ⓘ |
| substrateOf |
artemisinin
NERFINISHED
ⓘ
bupropion NERFINISHED ⓘ clopidogrel NERFINISHED ⓘ cyclophosphamide NERFINISHED ⓘ diazepam ⓘ efavirenz NERFINISHED ⓘ ifosfamide NERFINISHED ⓘ ketamine NERFINISHED ⓘ methadone NERFINISHED ⓘ nevirapine NERFINISHED ⓘ propofol ⓘ sertraline NERFINISHED ⓘ tamoxifen NERFINISHED ⓘ thiotepa ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Velpatasvir