PI3K-AKT signaling pathway
E902875
The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
Statements (73)
| Predicate | Object |
|---|---|
| instanceOf |
cell signaling pathway
ⓘ
intracellular signaling cascade ⓘ |
| activatedBy |
cytokines
ⓘ
growth factors ⓘ insulin NERFINISHED ⓘ oncogenic mutations ⓘ |
| associatedWith |
breast cancer
ⓘ
cancer ⓘ colorectal cancer ⓘ developmental disorders ⓘ endometrial cancer ⓘ glioblastoma ⓘ insulin resistance ⓘ lung cancer ⓘ overgrowth syndromes ⓘ prostate cancer ⓘ type 2 diabetes NERFINISHED ⓘ |
| downstreamOf |
IGF1 signaling
ⓘ
insulin signaling ⓘ receptor tyrosine kinases ⓘ |
| dysregulatedIn | many human cancers ⓘ |
| hasClinicalRelevance |
target for anticancer therapy
ⓘ
target for metabolic disease therapy ⓘ |
| hasComponent |
4E-BP1
NERFINISHED
ⓘ
AKT serine threonine kinase ⓘ BAD protein NERFINISHED ⓘ EGF receptor NERFINISHED ⓘ FOXO transcription factors NERFINISHED ⓘ G protein-coupled receptors ⓘ GSK3 beta NERFINISHED ⓘ IGF1 receptor NERFINISHED ⓘ MDM2 NERFINISHED ⓘ PDGF receptor NERFINISHED ⓘ PDK1 NERFINISHED ⓘ PTEN phosphatase NERFINISHED ⓘ TSC1 TSC2 complex NERFINISHED ⓘ class I PI3K catalytic subunits ⓘ class I PI3K regulatory subunits ⓘ insulin receptor ⓘ mTOR complex 1 NERFINISHED ⓘ mTOR complex 2 NERFINISHED ⓘ p70S6 kinase NERFINISHED ⓘ phosphatidylinositol 3 4 5-trisphosphate ⓘ phosphatidylinositol 4 5-bisphosphate ⓘ phosphoinositide 3-kinase ⓘ receptor tyrosine kinases ⓘ |
| inhibitedBy |
AKT inhibitors
ⓘ
PI3K inhibitors ⓘ PTEN NERFINISHED ⓘ mTOR inhibitors ⓘ |
| locatedIn |
cytoplasm
ⓘ
nucleus ⓘ plasma membrane ⓘ |
| partOf |
cell survival signaling network
ⓘ
insulin signaling pathway ⓘ oncogenic signaling networks ⓘ |
| regulates |
angiogenesis
ⓘ
apoptosis ⓘ autophagy ⓘ cell cycle progression ⓘ cell growth ⓘ cell metabolism ⓘ cell migration ⓘ cell proliferation ⓘ cell survival ⓘ cell survival under stress ⓘ glucose uptake ⓘ glycogen synthesis ⓘ protein synthesis ⓘ |
| upstreamOf |
FOXO transcriptional regulation
ⓘ
GSK3 beta inhibition ⓘ mTOR signaling pathway NERFINISHED ⓘ protein translation initiation ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.