Triple

T11074237
Position Surface form Disambiguated ID Type / Status
Subject HER2 receptor E261824 entity
Predicate activatesPathway P38196 FINISHED
Object PI3K-AKT signaling pathway
The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
 E902875 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: PI3K-AKT signaling pathway | Statement: [HER2 receptor, activatesPathway, PI3K-AKT signaling pathway]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07 
Target entity: PI3K-AKT signaling pathway
Context triple: [HER2 receptor, activatesPathway, PI3K-AKT signaling pathway]
  • A. Reactome pathways
    Reactome pathways are curated, peer-reviewed biological pathways that map molecular interactions and processes in human biology and other species.
  • B. AKT
    AKT is the IATA airport code for RAF Akrotiri, a Royal Air Force station and military airbase located on the island of Cyprus.
  • C. PLCγ2
    PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
  • D. Toll-like receptor signaling pathway
    The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
  • E. KEGG pathways
    KEGG pathways are curated biological pathway maps in the KEGG database that represent networks of molecular interactions, reactions, and relations involved in cellular and organismal processes.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: PI3K-AKT signaling pathway
Triple: [HER2 receptor, activatesPathway, PI3K-AKT signaling pathway]
Generated description
The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07 
Target entity: PI3K-AKT signaling pathway
Target entity description: The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
  • A. Reactome pathways
    Reactome pathways are curated, peer-reviewed biological pathways that map molecular interactions and processes in human biology and other species.
  • B. AKT
    AKT is the IATA airport code for RAF Akrotiri, a Royal Air Force station and military airbase located on the island of Cyprus.
  • C. PLCγ2
    PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
  • D. Toll-like receptor signaling pathway
    The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
  • E. KEGG pathways
    KEGG pathways are curated biological pathway maps in the KEGG database that represent networks of molecular interactions, reactions, and relations involved in cellular and organismal processes.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d6aa9983c08190b0ef61603b69feac completed April 8, 2026, 7:20 p.m.
NER Named-entity recognition batch_69d7994e32fc8190a6591d9e82b68f75 completed April 9, 2026, 12:19 p.m.
NED1 Entity disambiguation (via context triple) batch_69e3c8cc77988190aad54f56dbd0f8cf completed April 18, 2026, 6:09 p.m.
NEDg Description generation batch_69e3cefc00148190a1850dc6e31523c3 completed April 18, 2026, 6:35 p.m.
NED2 Entity disambiguation (via description) batch_69e3d014a644819092c76aa02b573ca9 completed April 18, 2026, 6:40 p.m.
Created at: April 8, 2026, 9:26 p.m.