ERBB3
E902873
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
ErbB family member
ⓘ
protein-coding gene ⓘ receptor tyrosine kinase ⓘ |
| activatesPathway |
PI3K-AKT pathway
NERFINISHED
ⓘ
RAS-RAF-MEK-ERK pathway ⓘ mTOR signaling pathway ⓘ |
| alsoKnownAs |
ERBB3 proto-oncogene
NERFINISHED
ⓘ
HER3 NERFINISHED ⓘ v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 NERFINISHED ⓘ |
| associatedWithDisease |
breast cancer
ⓘ
colorectal cancer ⓘ gastric cancer ⓘ lung cancer ⓘ melanoma ⓘ ovarian cancer ⓘ prostate cancer ⓘ |
| belongsToFamily |
EGFR family
NERFINISHED
ⓘ
ErbB receptor family NERFINISHED ⓘ |
| bindsLigand |
neuregulin 1 (NRG1)
NERFINISHED
ⓘ
neuregulin 2 (NRG2) NERFINISHED ⓘ |
| databaseIdentifier |
Entrez Gene:2065
NERFINISHED
ⓘ
HGNC:3431 ⓘ UniProt:P21860 ⓘ |
| encodes | Receptor tyrosine-protein kinase erbB-3 NERFINISHED ⓘ |
| expressedIn |
epithelial tissues
ⓘ
gastrointestinal tract ⓘ lung tissue ⓘ mammary gland ⓘ |
| formsHeterodimerWith |
EGFR (ERBB1)
NERFINISHED
ⓘ
ERBB2 (HER2) NERFINISHED ⓘ ERBB4 NERFINISHED ⓘ |
| hasBiologicalProcess |
MAPK signaling pathway
ⓘ
PI3K-AKT signaling pathway NERFINISHED ⓘ cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ epithelial cell development ⓘ mammary gland development ⓘ signal transduction ⓘ |
| hasCellularComponent |
cell surface
ⓘ
integral component of membrane ⓘ plasma membrane ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase-like domain ⓘ multiple tyrosine phosphorylation sites ⓘ single-pass transmembrane domain ⓘ |
| hasMolecularFunction |
neuregulin binding
ⓘ
protein tyrosine kinase activity (impaired intrinsic kinase) ⓘ receptor activity ⓘ |
| isDrugTarget |
monoclonal antibodies against HER3
ⓘ
pan-ErbB inhibitors ⓘ |
| locatedOnChromosome | human chromosome 12q13 ⓘ |
| organism | Homo sapiens ⓘ |
| postTranslationalModification |
glycosylation
ⓘ
tyrosine phosphorylation ⓘ |
| regulatedBy |
ligand-induced dimerization
ⓘ
receptor internalization and degradation ⓘ |
| roleInCancer |
contributes to therapy resistance
GENERATED
ⓘ
oncogenic signaling mediator GENERATED ⓘ promotes tumor cell proliferation GENERATED ⓘ promotes tumor cell survival GENERATED ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.