topiramate
E874309
Topiramate is an anticonvulsant medication commonly used to treat various forms of epilepsy and prevent migraines.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
anticonvulsant drug
ⓘ
antiepileptic drug ⓘ sulfamate-substituted monosaccharide ⓘ |
| affectsMolecularTarget |
AMPA/kainate glutamate receptors
ⓘ
GABA-A receptors ⓘ voltage-gated sodium channels ⓘ |
| hasATCCode | N03AX11 ⓘ |
| hasBioavailability | about 80–90% ⓘ |
| hasBrandName |
Topamax
NERFINISHED
ⓘ
Topiragen NERFINISHED ⓘ |
| hasChemicalFormula | C12H21NO8S ⓘ |
| hasEliminationHalfLife | about 21 hours in adults ⓘ |
| hasIUPACName | 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamate ⓘ |
| hasLegalStatus | prescription-only medicine ⓘ |
| hasMechanismOfAction |
antagonizes AMPA/kainate glutamate receptors
ⓘ
blocks voltage-dependent sodium channels ⓘ enhances GABAergic inhibition ⓘ weak carbonic anhydrase inhibition ⓘ |
| hasMolarMass | 339.36 g/mol ⓘ |
| hasPregnancyRisk | teratogenic potential ⓘ |
| hasPrimaryElimination | renal excretion unchanged GENERATED ⓘ |
| hasProteinBinding | 13–17% ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| inhibits | carbonic anhydrase isoenzymes II and IV ⓘ |
| interactsWith |
CNS depressants
NERFINISHED
ⓘ
oral contraceptives ⓘ valproic acid ⓘ |
| isAvailableAs |
extended-release formulations
ⓘ
immediate-release tablets ⓘ sprinkle capsules ⓘ |
| isContraindicatedWith |
history of metabolic acidosis
ⓘ
hypersensitivity to topiramate ⓘ |
| isExcretedBy | kidney ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines NERFINISHED ⓘ |
| isMetabolizedBy | liver (minor extent) ⓘ |
| isUsedInCombinationWith | phentermine for weight management ⓘ |
| mayCauseAdverseEffect |
cognitive slowing
ⓘ
fatigue ⓘ glaucoma ⓘ kidney stones ⓘ metabolic acidosis ⓘ paresthesia ⓘ weight loss ⓘ |
| prevents | migraine headaches ⓘ |
| treats |
Lennox–Gastaut syndrome
NERFINISHED
ⓘ
epilepsy ⓘ partial-onset seizures ⓘ primary generalized tonic-clonic seizures ⓘ |
| wasFirstApprovedIn | 1996 ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.