VKORC1
E852347
VKORC1 is an enzyme involved in vitamin K recycling that plays a key role in blood clotting and is the primary molecular target of the anticoagulant drug warfarin.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
protein-coding gene ⓘ |
| associatedWith |
anticoagulant sensitivity
ⓘ
bleeding risk under warfarin therapy ⓘ warfarin dose variability ⓘ |
| biologicalProcess |
blood coagulation
ⓘ
gamma-carboxylation of glutamate residues ⓘ vitamin K cycle ⓘ |
| cellularComponent | endoplasmic reticulum membrane ⓘ |
| chromosomalBand | 16p11.2 ⓘ |
| clinicalUse | pharmacogenetic marker for warfarin dosing ⓘ |
| diseaseAssociation |
vitamin K–dependent clotting factor deficiency type 2 (VKCFD2)
ⓘ
warfarin resistance ⓘ |
| encodes | vitamin K epoxide reductase complex subunit 1 protein NERFINISHED ⓘ |
| enzymeCommissionNumber | EC 1.17.4.4 ⓘ |
| expression |
liver
ⓘ
vascular tissues ⓘ |
| fullName | vitamin K epoxide reductase complex subunit 1 NERFINISHED ⓘ |
| geneID | VKORC1 (HGNC:12621) NERFINISHED ⓘ |
| inheritanceOfDeficiency | autosomal recessive ⓘ |
| locatedOnChromosome | human chromosome 16 ⓘ |
| molecularFunction |
oxidoreductase activity
ⓘ
vitamin K epoxide reductase (warfarin-sensitive) NERFINISHED ⓘ |
| orthologIn |
Bos taurus
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ Rattus norvegicus NERFINISHED ⓘ |
| pathway |
vitamin K-dependent clotting factor activation pathway
ⓘ
warfarin pharmacodynamics pathway ⓘ |
| polymorphism |
-1639G>A (c.-1639G>A)
ⓘ
1173C>T (c.1173C>T intronic variant) ⓘ rs9923231 NERFINISHED ⓘ rs9934438 NERFINISHED ⓘ |
| polymorphismEffect |
alters VKORC1 expression
ⓘ
modulates warfarin dose requirement ⓘ |
| product | vitamin K hydroquinone ⓘ |
| requiredForActivationOf |
coagulation factor IX
ⓘ
coagulation factor VII ⓘ coagulation factor X ⓘ protein C NERFINISHED ⓘ protein S ⓘ protein Z NERFINISHED ⓘ prothrombin (factor II) NERFINISHED ⓘ |
| substrate | vitamin K epoxide ⓘ |
| targetOf |
acenocoumarol
ⓘ
coumarin anticoagulants ⓘ phenprocoumon NERFINISHED ⓘ warfarin NERFINISHED ⓘ |
| topology | multi-pass membrane protein ⓘ |
| uniprotID | Q9BQB6 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.