constitutive androstane receptor
E850016
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
gene product
ⓘ
ligand-activated transcription factor ⓘ nuclear receptor ⓘ protein ⓘ xenobiotic sensor ⓘ |
| activatedBy |
CITCO
NERFINISHED
ⓘ
TCPOBOP ⓘ carbamazepine ⓘ endogenous metabolites ⓘ phenobarbital NERFINISHED ⓘ phenytoin NERFINISHED ⓘ rifampicin (human CAR) ⓘ xenobiotics ⓘ |
| alsoKnownAs |
CAR
ⓘ
NR1I3 NERFINISHED ⓘ nuclear receptor subfamily 1 group I member 3 NERFINISHED ⓘ |
| belongsToFamily | nuclear receptor subfamily 1 ⓘ |
| belongsToSubfamily | NR1I subfamily NERFINISHED ⓘ |
| belongsToSuperfamily | nuclear hormone receptors ⓘ |
| bindsDNAAs | heterodimer with RXR ⓘ |
| bindsToResponseElement |
DR4-type nuclear receptor response elements
ⓘ
phenobarbital-responsive enhancer module ⓘ |
| cellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| chromosomalLocationHuman | 1q23.3 ⓘ |
| discoveredIn | 1990s ⓘ |
| encodedByGene | NR1I3 NERFINISHED ⓘ |
| expressedInSpecies |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus ⓘ |
| expressedInTissue |
intestine
ⓘ
liver ⓘ |
| formsHeterodimerWith | retinoid X receptor alpha NERFINISHED ⓘ |
| hasConstitutiveActivity | yes GENERATED ⓘ |
| hasDomain |
DNA-binding domain
ⓘ
ligand-binding domain ⓘ |
| hasOrtholog | mouse Car (Nr1i3) NERFINISHED ⓘ |
| hasTransactivationFunction |
AF-1 domain
ⓘ
AF-2 domain ⓘ |
| inhibitedBy |
androstanol
ⓘ
androstenol ⓘ |
| interactsWith |
coactivator PGC-1alpha
NERFINISHED
ⓘ
coactivator SRC-1 NERFINISHED ⓘ corepressor NCoR NERFINISHED ⓘ corepressor SMRT NERFINISHED ⓘ |
| involvedIn |
chemical-induced liver hypertrophy
ⓘ
drug–drug interactions ⓘ xenobiotic-induced liver tumor promotion in rodents ⓘ |
| ligandType | endogenous and exogenous chemicals ⓘ |
| primarySiteOfExpression | liver GENERATED ⓘ |
| regulatedBy |
nuclear translocation
ⓘ
phosphorylation ⓘ |
| regulatesBiologicalProcess |
bile acid homeostasis
ⓘ
bilirubin clearance ⓘ drug metabolism ⓘ energy metabolism ⓘ xenobiotic detoxification ⓘ |
| upregulatesExpressionOf |
ABCB1 (P-glycoprotein)
NERFINISHED
ⓘ
ABCC2 (MRP2) NERFINISHED ⓘ CYP2B10 (mouse) NERFINISHED ⓘ CYP2B6 NERFINISHED ⓘ CYP2C9 NERFINISHED ⓘ CYP3A4 NERFINISHED ⓘ SLCO1B1 (OATP1B1) NERFINISHED ⓘ SULT2A1 ⓘ UGT1A1 NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.