Triple
T10214786
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | CYP3A4 |
E242412
|
entity |
| Predicate | regulatedBy |
P86
|
FINISHED |
| Object |
constitutive androstane receptor
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
|
E850016
|
NE FINISHED |
How this triple was built (4 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: constitutive androstane receptor | Statement: [CYP3A4, regulatedBy, constitutive androstane receptor]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: constitutive androstane receptor Context triple: [CYP3A4, regulatedBy, constitutive androstane receptor]
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg
Description generation
gpt-5.1
Instruction
Generate a one-sentence description of the target entity. You are given a context triple in the form (subject, predicate, object), where the object is the target entity. # Instructions Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. Avoid repeating the information from the triple, unless really essential. # Response Format Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: constitutive androstane receptor Triple: [CYP3A4, regulatedBy, constitutive androstane receptor]
Generated description
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: constitutive androstane receptor Target entity description: The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
Provenance (5 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69d381ae26c48190985abd0e25ee5d04 |
completed | April 6, 2026, 9:49 a.m. |
| NER | Named-entity recognition | batch_69d3aa273bdc8190bc4cf67a7923cebc |
completed | April 6, 2026, 12:42 p.m. |
| NED1 | Entity disambiguation (via context triple) | batch_69d652ea80dc81908bc65ee2ec390467 |
completed | April 8, 2026, 1:06 p.m. |
| NEDg | Description generation | batch_69d657818b008190a24170717cff53b9 |
completed | April 8, 2026, 1:26 p.m. |
| NED2 | Entity disambiguation (via description) | batch_69d65835a11c819083d069ab0f644d4c |
completed | April 8, 2026, 1:29 p.m. |
Created at: April 6, 2026, 11:04 a.m.