FOLFIRI regimen
E823219
The FOLFIRI regimen is a combination chemotherapy protocol, typically including folinic acid, fluorouracil, and irinotecan, commonly used to treat advanced colorectal cancer.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf | chemotherapy regimen ⓘ |
| commonAdverseEffect |
alopecia
ⓘ
anemia ⓘ diarrhea ⓘ fatigue ⓘ mucositis ⓘ nausea ⓘ neutropenia ⓘ thrombocytopenia ⓘ vomiting ⓘ |
| comparedWith | FOLFOX regimen NERFINISHED ⓘ |
| contraindicationComponent | irinotecan is contraindicated in severe hepatic impairment ⓘ |
| doseAdjustment | dose reduction may be required in patients with UGT1A1*28 polymorphism for irinotecan ⓘ |
| drugClassComponent |
fluorouracil is an antimetabolite
ⓘ
folinic acid is a reduced folate ⓘ irinotecan is a topoisomerase I inhibitor NERFINISHED ⓘ |
| fullName | folinic acid, fluorouracil, and irinotecan regimen NERFINISHED ⓘ |
| hasComponent |
5-fluorouracil
ⓘ
fluorouracil NERFINISHED ⓘ folinic acid ⓘ irinotecan NERFINISHED ⓘ leucovorin ⓘ |
| indicationContext |
treatment of metastatic colorectal cancer regardless of RAS status when combined with bevacizumab
ⓘ
treatment of metastatic colorectal cancer with RAS wild-type tumors when combined with anti-EGFR therapy ⓘ |
| mechanismComponent |
fluorouracil inhibits thymidylate synthase
ⓘ
folinic acid enhances binding of fluorouracil to thymidylate synthase ⓘ irinotecan inhibits DNA topoisomerase I ⓘ |
| oftenCombinedWith |
aflibercept
NERFINISHED
ⓘ
bevacizumab NERFINISHED ⓘ cetuximab ⓘ panitumumab NERFINISHED ⓘ ramucirumab ⓘ |
| requiresMonitoring |
complete blood count
ⓘ
liver function tests ⓘ renal function ⓘ |
| routeOfAdministration | intravenous ⓘ |
| seriousAdverseEffect |
febrile neutropenia
ⓘ
gastrointestinal perforation when combined with bevacizumab ⓘ severe diarrhea ⓘ |
| typicalSchedule |
biweekly regimen
ⓘ
repeated every 2 weeks ⓘ |
| usedAs |
first-line therapy for metastatic colorectal cancer
ⓘ
second-line therapy for metastatic colorectal cancer ⓘ |
| usedFor |
advanced colorectal cancer
ⓘ
metastatic colorectal cancer ⓘ recurrent colorectal cancer ⓘ unresectable colorectal cancer ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.