programmed cell death protein 1

E822411

cell surface receptor immune checkpoint receptor inhibitory receptor protein transmembrane protein

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor on T cells that downregulates immune responses and promotes self-tolerance, making it a key target in cancer immunotherapy.

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Observed surface forms (1)

Surface form	Occurrences
PD-1	1

Statements (75)

Predicate	Object
instanceOf	cell surface receptor ⓘ immune checkpoint receptor ⓘ inhibitory receptor ⓘ protein ⓘ transmembrane protein ⓘ
associatedWithDisease	Hodgkin lymphoma NERFINISHED ⓘ autoimmune diseases ⓘ hepatocellular carcinoma ⓘ melanoma ⓘ non-small cell lung cancer NERFINISHED ⓘ renal cell carcinoma ⓘ various solid tumors ⓘ
associatedWithProcess	cancer immune evasion ⓘ immune checkpoint pathway ⓘ
bindsTo	programmed death-ligand 1 NERFINISHED ⓘ programmed death-ligand 2 NERFINISHED ⓘ
biologicalProcess	induction of T cell exhaustion ⓘ maintenance of peripheral tolerance ⓘ negative regulation of T cell activation ⓘ negative regulation of cell proliferation ⓘ negative regulation of cytokine production ⓘ negative regulation of immune response ⓘ
cellularComponent	external side of plasma membrane ⓘ integral component of membrane ⓘ plasma membrane ⓘ
discoveredBy	Tasuku Honjo NERFINISHED ⓘ
discoveryYear	1992 ⓘ
encodedByGene	PDCD1 NERFINISHED ⓘ
expressedOnCellType	B cells ⓘ T cells ⓘ activated T cells ⓘ dendritic cells ⓘ exhausted T cells ⓘ monocytes ⓘ natural killer cells ⓘ
foundInOrganism	Homo sapiens NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ
hasDomain	cytoplasmic tail ⓘ extracellular IgV-like domain ⓘ transmembrane domain ⓘ
hasLigand	PD-L1 NERFINISHED ⓘ PD-L2 NERFINISHED ⓘ
hasMotif	ITIM motif ⓘ ITSM motif ⓘ
hasSynonym	CD279 NERFINISHED ⓘ PD-1 NERFINISHED ⓘ
inhibitionEffect	enhances anti-tumor immune response ⓘ increases T cell proliferation ⓘ increases cytokine production ⓘ
lengthInAminoAcids	288 ⓘ
locatedOnChromosome	human chromosome 2q37.3 ⓘ
molecularFunction	inhibitory signaling receptor activity ⓘ protein binding ⓘ
orthologInMouse	Pdcd1 NERFINISHED ⓘ
pdbStructureAvailable	true ⓘ
postTranslationalModification	N-linked glycosylation ⓘ
regulation	upregulated in chronic antigen stimulation ⓘ upregulated upon T cell activation ⓘ
roleInTolerance	prevents autoimmunity ⓘ promotes self-tolerance ⓘ
signalTransduction	inhibits CD28 costimulatory signaling ⓘ inhibits T cell receptor signaling ⓘ recruits SHP-1 phosphatase ⓘ recruits SHP-2 phosphatase ⓘ
targetOfDrug	camrelizumab NERFINISHED ⓘ cemiplimab NERFINISHED ⓘ nivolumab NERFINISHED ⓘ pembrolizumab ⓘ sintilimab NERFINISHED ⓘ spartalizumab NERFINISHED ⓘ tislelizumab NERFINISHED ⓘ toripalimab NERFINISHED ⓘ
therapeuticArea	cancer immunotherapy ⓘ immune checkpoint blockade ⓘ
uniprotID	Q15116 ⓘ

Referenced by (3)

Full triples — surface form annotated when it differs from this entity's canonical label.

programmed death-ligand 1 → bindsTo → programmed cell death protein 1 ⓘ

Tasuku Honjo → discovered → programmed cell death protein 1 ⓘ

this entity surface form: PD-1