catechol-O-methyltransferase
E804594
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
methyltransferase ⓘ transferase ⓘ |
| associatedWith |
cognitive function variation
ⓘ
pain sensitivity variation ⓘ risk of anxiety disorders ⓘ risk of schizophrenia ⓘ |
| biologicalProcess |
catecholamine catabolic process
ⓘ
dopamine catabolic process ⓘ epinephrine catabolic process ⓘ inactivation of catecholamine neurotransmitters ⓘ norepinephrine catabolic process ⓘ regulation of synaptic transmission ⓘ xenobiotic metabolic process ⓘ |
| catalyzesReaction | transfer of a methyl group from S-adenosyl-L-methionine to catechol substrates ⓘ |
| cellularLocation |
cytosol
ⓘ
plasma membrane ⓘ |
| chromosomalLocation | 22q11.21 (human COMT gene) ⓘ |
| drugTargetOf |
entacapone
NERFINISHED
ⓘ
opicapone ⓘ tolcapone NERFINISHED ⓘ |
| encodedByGene |
COMT (human)
NERFINISHED
ⓘ
Comt (mouse) NERFINISHED ⓘ Comt (rat) ⓘ |
| expressedInTissue |
blood cells
ⓘ
brain ⓘ intestinal tract ⓘ kidney ⓘ liver ⓘ |
| foundInOrganism |
Homo sapiens
NERFINISHED
ⓘ
Mus musculus NERFINISHED ⓘ Rattus norvegicus NERFINISHED ⓘ |
| hasECNumber | 2.1.1.6 ⓘ |
| hasGeneSymbol | COMT ⓘ |
| hasIsoform |
membrane-bound COMT
ⓘ
soluble COMT ⓘ |
| hasPolymorphism | Val158Met (rs4680) ⓘ |
| inhibitionUse | adjunct therapy in Parkinson’s disease ⓘ |
| modifiesMolecule |
L-DOPA
NERFINISHED
ⓘ
catechol estrogens ⓘ catecholamines ⓘ dopamine ⓘ epinephrine ⓘ norepinephrine ⓘ |
| molecularFunction |
S-adenosylmethionine-dependent methyltransferase activity
ⓘ
catechol O-methyltransferase activity ⓘ |
| pathway |
catecholamine metabolism
ⓘ
dopaminergic synapse ⓘ estrogen metabolism ⓘ |
| producesProduct | S-adenosyl-L-homocysteine NERFINISHED ⓘ |
| usesCofactor | S-adenosyl-L-methionine ⓘ |
| Val158MetEffect | alters enzymatic activity and thermostability ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.