Thomas logical formalism for regulatory networks
E68059
discrete dynamical system framework
mathematical formalism
modeling approach for gene regulatory networks
qualitative modeling framework
Thomas logical formalism for regulatory networks is a qualitative mathematical framework that models gene and regulatory networks using discrete logical variables and rules to capture their dynamic behavior.
Statements (40)
| Predicate | Object |
|---|---|
| instanceOf |
discrete dynamical system framework
ⓘ
mathematical formalism ⓘ modeling approach for gene regulatory networks ⓘ qualitative modeling framework ⓘ |
| aimsTo | provide qualitative understanding of complex regulatory systems ⓘ |
| appliesTo |
cellular regulatory networks
ⓘ
gene regulatory networks ⓘ |
| assumes |
discrete state space
ⓘ
logical update rules ⓘ |
| captures |
dynamic behavior of regulatory networks
ⓘ
state transitions of regulatory components ⓘ |
| characterizedBy |
piecewise constant activity levels
ⓘ
use of thresholds for regulatory effects ⓘ |
| contrastsWith | continuous differential equation models ⓘ |
| developedBy | René Thomas ⓘ |
| enables |
analysis of attractors
ⓘ
analysis of oscillatory behaviors ⓘ analysis of stable states ⓘ |
| field |
computational biology
ⓘ
mathematical biology ⓘ systems biology ⓘ |
| focusesOn | structure-dynamics relationship in regulatory networks ⓘ |
| influenced | development of logical modeling tools in systems biology ⓘ |
| models |
qualitative dynamics
ⓘ
time evolution of gene activity levels ⓘ |
| originatedIn | late 20th century ⓘ |
| relatedTo |
Boolean network models
ⓘ
multi-valued logical network models ⓘ |
| represents |
activation relationships
ⓘ
inhibition relationships ⓘ regulatory interactions ⓘ |
| supports |
asynchronous update schemes
ⓘ
synchronous update schemes ⓘ |
| usedFor |
hypothesis generation in systems biology
ⓘ
modeling cell cycle regulation ⓘ modeling cell differentiation processes ⓘ qualitative simulation of regulatory networks ⓘ |
| uses |
discrete logical variables
ⓘ
logical rules ⓘ multi-valued logical variables ⓘ |
Referenced by (1)
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