CYP2C9
E567200
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ protein-coding gene ⓘ |
| associatedWith | adverse drug reactions when activity is altered ⓘ |
| biologicalProcess |
arachidonic acid metabolism
ⓘ
drug clearance ⓘ oxidation of xenobiotics ⓘ |
| cellularLocation | endoplasmic reticulum ⓘ |
| clinicalRelevance |
pharmacogenomics of anticoagulant therapy
ⓘ
risk of warfarin-induced bleeding ⓘ |
| cofactor | heme ⓘ |
| encodes | cytochrome P450 2C9 protein ⓘ |
| expressedIn | liver ⓘ |
| fullName | cytochrome P450 family 2 subfamily C member 9 NERFINISHED ⓘ |
| geneID | 1559 ⓘ |
| hasMolecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| hasPolymorphism |
CYP2C9*11
NERFINISHED
ⓘ
CYP2C9*2 NERFINISHED ⓘ CYP2C9*3 NERFINISHED ⓘ CYP2C9*5 NERFINISHED ⓘ CYP2C9*6 NERFINISHED ⓘ CYP2C9*8 NERFINISHED ⓘ |
| inducedBy |
carbamazepine
NERFINISHED
ⓘ
rifampin ⓘ |
| inhibitedBy |
amiodarone
ⓘ
fluconazole NERFINISHED ⓘ sulfamethoxazole ⓘ |
| locatedIn | chromosome 10q23.33 ⓘ |
| memberOf |
CYP2C subfamily
NERFINISHED
ⓘ
cytochrome P450 superfamily NERFINISHED ⓘ |
| metabolizes |
S-warfarin
ⓘ
celecoxib NERFINISHED ⓘ diclofenac ⓘ fluvastatin ⓘ glipizide ⓘ ibuprofen ⓘ losartan NERFINISHED ⓘ many NSAIDs ⓘ many oral anticoagulants ⓘ phenytoin ⓘ tolbutamide ⓘ warfarin NERFINISHED ⓘ |
| pathway |
drug metabolism
ⓘ
xenobiotic metabolism ⓘ |
| polymorphismsAffect |
enzyme activity
ⓘ
warfarin dose requirements ⓘ |
| regulation | transcriptionally regulated by nuclear receptors ⓘ |
| species | Homo sapiens NERFINISHED ⓘ |
| substrateSpecificity | small lipophilic molecules ⓘ |
| uniprotID | P11712 ⓘ |
| usesCofactor | NADPH ⓘ |
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.