Gemin3
E564272
Gemin3 is an RNA helicase and core component of the SMN complex that plays a crucial role in the assembly and metabolism of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing.
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
RNA helicase
ⓘ
protein ⓘ |
| associatedWithDisease | spinal muscular atrophy pathway dysfunction ⓘ |
| associatedWithProcess | neuronal RNA processing ⓘ |
| binds | RNA ⓘ |
| biologicalRole |
core component of SMN complex
ⓘ
facilitates assembly of snRNPs ⓘ participates in pre-mRNA splicing machinery ⓘ |
| cellularComponent |
SMN complex
NERFINISHED
ⓘ
cytoplasmic ribonucleoprotein granules ⓘ nucleoplasm ⓘ |
| conservedIn | vertebrates ⓘ |
| encodedBy | DDX20 gene NERFINISHED ⓘ |
| foundInTissue |
neuronal tissue
ⓘ
ubiquitously expressed tissues ⓘ |
| hasAlternativeName |
DDX20
NERFINISHED
ⓘ
DEAD-box helicase 20 NERFINISHED ⓘ GEM-associated protein 3 NERFINISHED ⓘ |
| hasDomain | DEAD-box helicase domain ⓘ |
| hasEnzymeClass | helicase ⓘ |
| hasLength | approximately 824 amino acids ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
ATP-dependent RNA helicase activity ⓘ RNA binding ⓘ |
| hasMotif | DEAD motif (Asp-Glu-Ala-Asp) ⓘ |
| interactsWith |
Gemin2
ⓘ
Gemin4 NERFINISHED ⓘ SMN1 protein NERFINISHED ⓘ spliceosomal snRNP proteins ⓘ |
| involvedIn |
RNA metabolism
ⓘ
U snRNA processing ⓘ pre-mRNA splicing ⓘ small nuclear ribonucleoprotein (snRNP) biogenesis ⓘ snRNP assembly ⓘ spliceosomal snRNP maturation ⓘ |
| locatedIn |
Gems (Gemini of Cajal bodies)
NERFINISHED
ⓘ
cytoplasm ⓘ nucleus ⓘ |
| organism | Homo sapiens ⓘ |
| partOf | SMN complex NERFINISHED ⓘ |
| regulates |
snRNP assembly dynamics
ⓘ
snRNP stability ⓘ |
| requiresCofactor | ATP ⓘ |
| subcellularLocalization |
Cajal bodies-associated structures
ⓘ
nuclear gems ⓘ |
| taxon | Eukaryota NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein