Sm proteins
E561090
Sm proteins are a family of small, evolutionarily conserved RNA-binding proteins that form the core of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing in eukaryotic cells.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
RNA-binding protein
ⓘ
eukaryotic protein complex component ⓘ protein family ⓘ |
| bindsMolecule |
RNA
ⓘ
small nuclear RNA ⓘ |
| bindsSequenceMotif |
AU-rich Sm site
ⓘ
Sm site ⓘ |
| formsComplexWith |
U1 snRNA
NERFINISHED
ⓘ
U2 snRNA ⓘ U4 snRNA NERFINISHED ⓘ U5 snRNA ⓘ |
| formsPartOf |
small nuclear ribonucleoproteins
ⓘ
snRNP core ⓘ |
| hasAlternativeName |
Sm core proteins
NERFINISHED
ⓘ
Sm-class proteins ⓘ |
| hasMember |
SmB
NERFINISHED
ⓘ
SmB' ⓘ SmD1 NERFINISHED ⓘ SmD2 NERFINISHED ⓘ SmD3 NERFINISHED ⓘ SmE NERFINISHED ⓘ SmF NERFINISHED ⓘ SmG NERFINISHED ⓘ |
| hasMolecularFunction |
RNA binding
ⓘ
snRNP assembly factor binding ⓘ |
| hasStructuralFeature |
Sm fold
ⓘ
beta-sheet rich domain ⓘ |
| interactsWith |
Gemin proteins
NERFINISHED
ⓘ
SMN complex NERFINISHED ⓘ |
| isAbsentFrom | U6 snRNP NERFINISHED ⓘ |
| isAssociatedWithDisease | systemic lupus erythematosus ⓘ |
| isComponentOf |
U1 snRNP
NERFINISHED
ⓘ
U2 snRNP NERFINISHED ⓘ U4 snRNP NERFINISHED ⓘ U5 snRNP NERFINISHED ⓘ |
| isEncodedBy | multiple nuclear genes ⓘ |
| isEssentialFor |
pre-mRNA splicing
ⓘ
spliceosome function ⓘ |
| isEvolutionarilyConserved | true ⓘ |
| isPostTranslationallyModifiedBy |
methylation
ⓘ
phosphorylation ⓘ |
| isTargetOf | anti-Sm autoantibodies ⓘ |
| localizesTo |
Cajal bodies
NERFINISHED
ⓘ
nuclear speckles ⓘ nucleus ⓘ |
| occursIn | eukaryotic cells ⓘ |
| participatesIn |
pre-mRNA processing
ⓘ
snRNP biogenesis ⓘ spliceosome assembly ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein