posaconazole
E556658
Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
All labels observed (1)
| Label | Occurrences |
|---|---|
| posaconazole canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5931499 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: posaconazole Context triple: [Aspergillus fumigatus, treatedWith, posaconazole]
-
A.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
B.
velpatasvir
Velpatasvir is a direct-acting antiviral medication used in combination with sofosbuvir to treat chronic hepatitis C virus infection across multiple genotypes.
-
C.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
-
D.
Novafora
Novafora was a semiconductor company known for acquiring Transmeta to expand its presence in low-power microprocessor and video processing technologies.
-
E.
Efate
Efate is a central island of Vanuatu that hosts the nation’s capital, Port Vila, and serves as its main political and economic hub.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: posaconazole Target entity description: Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
-
A.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
B.
velpatasvir
Velpatasvir is a direct-acting antiviral medication used in combination with sofosbuvir to treat chronic hepatitis C virus infection across multiple genotypes.
-
C.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
-
D.
Novafora
Novafora was a semiconductor company known for acquiring Transmeta to expand its presence in low-power microprocessor and video processing technologies.
-
E.
Efate
Efate is a central island of Vanuatu that hosts the nation’s capital, Port Vila, and serves as its main political and economic hub.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
azole antifungal
ⓘ
broad-spectrum antifungal agent ⓘ pharmaceutical drug ⓘ triazole antifungal drug ⓘ |
| approvedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| approvedIn |
European Union
NERFINISHED
ⓘ
United States NERFINISHED ⓘ |
| belongsToPharmacologicClass | systemic antifungals ⓘ |
| contraindicatedWith | certain CYP3A4 substrates that prolong QT interval ⓘ |
| developedBy |
Merck & Co.
NERFINISHED
ⓘ
Schering-Plough NERFINISHED ⓘ |
| discoveredIn | 1990s ⓘ |
| hasAdverseEffect |
QT interval prolongation
ⓘ
diarrhea ⓘ elevated liver enzymes ⓘ headache ⓘ nausea ⓘ vomiting ⓘ |
| hasATCCode | J02AC04 ⓘ |
| hasBioavailability | food-dependent ⓘ |
| hasChemicalClass | triazole ⓘ |
| hasDosageForm |
delayed-release oral tablet
ⓘ
intravenous solution ⓘ oral suspension ⓘ |
| hasHalfLife | approximately 25 to 35 hours ⓘ |
| hasPregnancyCategory | C (US, historical classification) ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasSpectrumOfActivity |
Aspergillus species
ⓘ
Candida species ⓘ Mucorales NERFINISHED ⓘ Zygomycetes NERFINISHED ⓘ |
| hasTarget | fungal CYP51 (lanosterol 14α-demethylase) ⓘ |
| highlyProteinBound | true ⓘ |
| indicatedFor |
hematopoietic stem cell transplant recipients with graft-versus-host disease
ⓘ
immunocompromised patients at high risk of fungal infections ⓘ patients with hematologic malignancies with prolonged neutropenia ⓘ |
| isAdministeredTo |
adolescents
ⓘ
adults ⓘ |
| mechanismOfAction |
inhibition of ergosterol synthesis in fungal cell membranes
ⓘ
inhibition of fungal lanosterol 14α-demethylase ⓘ |
| metabolizedBy | UDP-glucuronosyltransferase UGT1A4 NERFINISHED ⓘ |
| usedFor |
prevention of invasive fungal infections
ⓘ
prophylaxis of Aspergillus infections ⓘ prophylaxis of Candida infections ⓘ treatment of invasive fungal infections ⓘ treatment of mucormycosis ⓘ treatment of oropharyngeal candidiasis ⓘ treatment of zygomycosis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: posaconazole Description of subject: Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.