NMDA receptor
E494104
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
Statements (69)
| Predicate | Object |
|---|---|
| instanceOf |
ionotropic glutamate receptor
ⓘ
ligand-gated ion channel ⓘ membrane protein complex ⓘ |
| activatedBy |
N-methyl-D-aspartate
ⓘ
glutamate ⓘ |
| belongsTo | glutamatergic synapse pathway ⓘ |
| blockedBy | Mg2+ (voltage-dependent block) ⓘ |
| coAgonistRequired |
D-serine
ⓘ
glycine ⓘ |
| distinguishedFrom |
AMPA receptor
NERFINISHED
ⓘ
kainate receptor ⓘ |
| downstreamEffect |
Ca2+-dependent signaling cascades
ⓘ
gene expression changes ⓘ |
| encodedBy |
GRIN1
NERFINISHED
ⓘ
GRIN2A NERFINISHED ⓘ GRIN2B NERFINISHED ⓘ GRIN2C NERFINISHED ⓘ GRIN2D NERFINISHED ⓘ GRIN3A NERFINISHED ⓘ GRIN3B NERFINISHED ⓘ |
| fullName | N-methyl-D-aspartate receptor ⓘ |
| hasDomain |
intracellular C-terminal domain
ⓘ
ion channel pore domain ⓘ ligand-binding domain ⓘ |
| hasFunction |
coincidence detection of presynaptic and postsynaptic activity
ⓘ
mediates excitatory synaptic transmission ⓘ mediates synaptic plasticity ⓘ supports long-term depression ⓘ supports long-term potentiation ⓘ |
| hasKinetics | slow activation and deactivation compared to AMPA receptors ⓘ |
| hasSubunit |
GluN1
NERFINISHED
ⓘ
GluN2A NERFINISHED ⓘ GluN2B NERFINISHED ⓘ GluN2C NERFINISHED ⓘ GluN2D NERFINISHED ⓘ GluN3A NERFINISHED ⓘ GluN3B NERFINISHED ⓘ |
| implicatedIn |
Alzheimer's disease
NERFINISHED
ⓘ
Huntington's disease NERFINISHED ⓘ Parkinson's disease NERFINISHED ⓘ epilepsy ⓘ major depressive disorder ⓘ schizophrenia ⓘ stroke ⓘ traumatic brain injury ⓘ |
| interactsWith |
CaMKII
NERFINISHED
ⓘ
PSD-95 ⓘ |
| involvedIn |
learning
ⓘ
memory formation ⓘ neural development ⓘ synaptogenesis ⓘ |
| locatedIn |
central nervous system
ⓘ
cerebral cortex ⓘ hippocampus NERFINISHED ⓘ postsynaptic density ⓘ spinal cord ⓘ |
| modulatedBy |
polyamines
ⓘ
protons (pH) ⓘ zinc ⓘ |
| overactivationLeadsTo | excitotoxicity ⓘ |
| permeableTo |
Ca2+
ⓘ
K+ ⓘ Na+ ⓘ |
| pharmacologicallyBlockedBy |
MK-801
NERFINISHED
ⓘ
ketamine ⓘ memantine NERFINISHED ⓘ phencyclidine ⓘ |
| requires |
extracellular glycine-binding site occupancy
ⓘ
membrane depolarization for full activation ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.