Lipitor
E474929
Lipitor is a widely prescribed statin medication used to lower cholesterol and reduce the risk of cardiovascular disease.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
pharmaceutical drug ⓘ statin medication ⓘ |
| approvalBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| ATCCode | C10AA05 ⓘ |
| blackBoxWarning | contraindicated in pregnancy and lactation ⓘ |
| chemicalFormula | C33H35FN2O5 ⓘ |
| commonAdverseEffect |
diarrhea
ⓘ
dyspepsia ⓘ myalgia ⓘ nausea ⓘ |
| contraindication |
active liver disease
ⓘ
breastfeeding ⓘ pregnancy ⓘ unexplained persistent elevations of liver transaminases ⓘ |
| countryOfOrigin |
United States of America
ⓘ
surface form:
United States
|
| developer | Pfizer NERFINISHED ⓘ |
| dosageForm | oral tablet ⓘ |
| drugClass |
HMG-CoA reductase inhibitor
ⓘ
statin ⓘ |
| effect |
lowers LDL cholesterol
ⓘ
lowers total cholesterol ⓘ lowers triglycerides ⓘ modestly increases HDL cholesterol ⓘ |
| FDAApprovalYear | 1996 ⓘ |
| genericName | atorvastatin ⓘ |
| halfLife | approximately 14 hours ⓘ |
| hasGeneric | atorvastatin generic formulations ⓘ |
| indication |
hypercholesterolemia
ⓘ
mixed dyslipidemia ⓘ prevention of myocardial infarction ⓘ prevention of stroke ⓘ primary prevention of cardiovascular disease ⓘ secondary prevention of cardiovascular disease ⓘ treatment of heterozygous familial hypercholesterolemia ⓘ treatment of homozygous familial hypercholesterolemia ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| manufacturer | Pfizer NERFINISHED ⓘ |
| mechanismOfAction | inhibits HMG-CoA reductase ⓘ |
| metabolism | CYP3A4 NERFINISHED ⓘ |
| patentStatus | patent expired ⓘ |
| pregnancyCategory | contraindicated in pregnancy ⓘ |
| proteinBinding | high ⓘ |
| routeOfAdministration | oral ⓘ |
| seriousAdverseEffect |
hepatotoxicity
ⓘ
myopathy ⓘ rhabdomyolysis ⓘ |
| target | HMG-CoA reductase enzyme ⓘ |
| therapeuticArea | cardiovascular disease ⓘ |
| typicalDoseRange | 10–80 mg once daily ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.