neutral theory of population genetics
E473474
The neutral theory of population genetics is an evolutionary framework proposing that most genetic variation and molecular changes in populations are governed by random genetic drift of selectively neutral mutations rather than by natural selection.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
evolutionary theory
ⓘ
scientific theory ⓘ theory in population genetics ⓘ |
| addresses |
molecular evolution
ⓘ
polymorphism within populations ⓘ |
| alsoKnownAs | neutral theory of molecular evolution ⓘ |
| appliesTo |
many protein-coding sequence changes
ⓘ
noncoding DNA variation ⓘ synonymous substitutions ⓘ |
| assumes |
effective population size influences the fate of neutral mutations
ⓘ
many mutations have no effect on organismal fitness ⓘ |
| contrastsWith |
adaptive evolutionism at the molecular level
ⓘ
selectionist theory of molecular evolution ⓘ |
| coreClaim |
most evolutionary changes at the molecular level are caused by random genetic drift of selectively neutral mutations
ⓘ
most standing genetic variation within populations is selectively neutral or nearly neutral ⓘ |
| criticizedFor | underestimating the role of adaptive evolution at the molecular level ⓘ |
| downplaysProcess | positive natural selection ⓘ |
| emphasizesProcess |
genetic drift
ⓘ
mutation ⓘ |
| extendedBy | nearly neutral theory of molecular evolution NERFINISHED ⓘ |
| field |
evolutionary biology
ⓘ
population genetics ⓘ |
| influenced |
development of coalescent theory
ⓘ
interpretation of DNA sequence variation ⓘ molecular population genetics ⓘ |
| predicts |
heterozygosity depends on effective population size and neutral mutation rate
ⓘ
molecular clock-like constancy of substitution rates over time ⓘ most fixed differences between species at the molecular level are selectively neutral ⓘ rate of neutral molecular evolution equals neutral mutation rate ⓘ |
| proposedBy | Motoo Kimura NERFINISHED ⓘ |
| providesModelFor | expected site frequency spectrum under neutrality ⓘ |
| providesNullModelFor |
Hudson–Kreitman–Aguadé test
NERFINISHED
ⓘ
McDonald–Kreitman test NERFINISHED ⓘ Tajima's D NERFINISHED ⓘ tests of natural selection ⓘ |
| publicationAuthor | Motoo Kimura NERFINISHED ⓘ |
| publicationYear | 1983 ⓘ |
| publishedIn | The Neutral Theory of Molecular Evolution NERFINISHED ⓘ |
| relatedConcept |
coalescent process
ⓘ
effective population size ⓘ genetic drift ⓘ molecular clock ⓘ selectively neutral mutation ⓘ |
| supportsView | much molecular evolution is non-adaptive ⓘ |
| timePeriod | late 1960s ⓘ |
| usedIn |
detecting deviations from neutrality as evidence of selection
ⓘ
estimating effective population size from neutral markers ⓘ inferring demographic history from neutral loci ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
Unified Neutral Theory of Biodiversity and Biogeography
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basedOn
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neutral theory of population genetics
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